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Diagnostic performance of intraoperative assessment in grade 2 endometrioid endometrial carcinoma.
Bandala-Jacques, Antonio; Cantú-de-León, David; Pérez-Montiel, Delia; Salcedo-Hernández, Rosa A; Prada, Diddier; González-Enciso, Aarón; Gonzalez-Valdés, Arely; Barquet-Muñoz, Salim Abraham.
Afiliação
  • Bandala-Jacques A; Biomedical Cancer Research Unit, Instituto Nacional de Cancerología, Mexico City, Mexico.
  • Cantú-de-León D; Biomedical Investigations Institute, Universidad Nacional Autonóma de México, Mexico City, Mexico.
  • Pérez-Montiel D; Instituto Nacional de Cancerología, Mexico City, Mexico.
  • Salcedo-Hernández RA; Department of Pathology, Instituto Nacional de Cancerología, Mexico City, Mexico.
  • Prada D; Department of Gynecology, Instituto Nacional de Cancerología, Mexico City, Mexico.
  • González-Enciso A; Biomedical Cancer Research Unit, Instituto Nacional de Cancerología, Mexico City, Mexico.
  • Gonzalez-Valdés A; Department of Biomedical Informatics, Faculty of Medicine, Universidad Nacional Autónoma de México, Mexico City, Mexico.
  • Barquet-Muñoz SA; Department of Environmental Health Sciences, Mailman School of Public Health, Columbia University, New York City, USA.
World J Surg Oncol ; 18(1): 284, 2020 Oct 30.
Article em En | MEDLINE | ID: mdl-33126895
BACKGROUND: Endometrial carcinoma is the most common gynecologic malignancy in developed countries. Grade 2 carcinoma is associated with pelvic lymph-node metastasis, depending on selected risk factors. Intraoperative assessment (IOA) can identify patients at risk for lymph node metastasis who should undergo staging surgery. Our objective was to establish the diagnostic precision of IOA in determining the need for surgical staging in grade 2 endometrioid endometrial carcinoma. METHODS: Two hundred twenty-two patients underwent IOA. Results were compared to the final pathology report. The accuracy of the IOA parameters was calculated. Variables were evaluated in patients with positive versus negative IOA. Overall and disease-free survivals were calculated according to IOA, lymphadenectomy, and nodal metastasis. RESULTS: IOA was positive in 80 patients. It showed an accuracy of 76.13% when compared with the postoperative assessment. The best individual parameter was myometrial invasion. Nodal metastasis was observed in 16 patients in the positive IOA group and 7 patients in the negative group. Patients with lymph node metastasis had a 5-year overall survival rate of 80.9%, whereas patients without metastasis had a 5-year overall survival rate of 97.9%. CONCLUSIONS: IOA is an adequate tool to identify high-risk patients in grade 2 endometrial carcinoma. Myometrial invasion is the individual parameter that yields the highest diagnostic precision.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Neoplasias do Endométrio / Carcinoma Endometrioide Tipo de estudo: Diagnostic_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Limite: Female / Humans Idioma: En Revista: World J Surg Oncol Ano de publicação: 2020 Tipo de documento: Article País de afiliação: México País de publicação: Reino Unido
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Neoplasias do Endométrio / Carcinoma Endometrioide Tipo de estudo: Diagnostic_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Limite: Female / Humans Idioma: En Revista: World J Surg Oncol Ano de publicação: 2020 Tipo de documento: Article País de afiliação: México País de publicação: Reino Unido