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Prospective GERiatric Observational (ProGERO) study: cohort design and preliminary results.
Saraiva, Marcos Daniel; Rangel, Luís Fernando; Cunha, Julia Lusis Lassance; Rotta, Thereza Cristina Ariza; Douradinho, Christian; Khazaal, Eugênia Jatene Bou; Aliberti, Márlon Juliano Romero; Avelino-Silva, Thiago Junqueira; Apolinario, Daniel; Suemoto, Claudia Kimie; Jacob-Filho, Wilson.
Afiliação
  • Saraiva MD; Laboratorio de Investigacao Medica em Envelhecimento (LIM-66), Servico de Geriatria, Faculdade de Medicina, Hospital das Clinicas HCFMUSP, Universidade de Sao Paulo, Av. Dr. Eneas de Carvalho Aguiar 155, 8° andar, Setor Azul (Clinica Medica), LIM-66, Cerqueira Cesar, Sao Paulo, SP, 05403-000, Brazil
  • Rangel LF; Laboratorio de Investigacao Medica em Envelhecimento (LIM-66), Servico de Geriatria, Faculdade de Medicina, Hospital das Clinicas HCFMUSP, Universidade de Sao Paulo, Av. Dr. Eneas de Carvalho Aguiar 155, 8° andar, Setor Azul (Clinica Medica), LIM-66, Cerqueira Cesar, Sao Paulo, SP, 05403-000, Brazil
  • Cunha JLL; Laboratorio de Investigacao Medica em Envelhecimento (LIM-66), Servico de Geriatria, Faculdade de Medicina, Hospital das Clinicas HCFMUSP, Universidade de Sao Paulo, Av. Dr. Eneas de Carvalho Aguiar 155, 8° andar, Setor Azul (Clinica Medica), LIM-66, Cerqueira Cesar, Sao Paulo, SP, 05403-000, Brazil
  • Rotta TCA; Laboratorio de Investigacao Medica em Envelhecimento (LIM-66), Servico de Geriatria, Faculdade de Medicina, Hospital das Clinicas HCFMUSP, Universidade de Sao Paulo, Av. Dr. Eneas de Carvalho Aguiar 155, 8° andar, Setor Azul (Clinica Medica), LIM-66, Cerqueira Cesar, Sao Paulo, SP, 05403-000, Brazil
  • Douradinho C; Laboratorio de Investigacao Medica em Envelhecimento (LIM-66), Servico de Geriatria, Faculdade de Medicina, Hospital das Clinicas HCFMUSP, Universidade de Sao Paulo, Av. Dr. Eneas de Carvalho Aguiar 155, 8° andar, Setor Azul (Clinica Medica), LIM-66, Cerqueira Cesar, Sao Paulo, SP, 05403-000, Brazil
  • Khazaal EJB; Laboratorio de Investigacao Medica em Envelhecimento (LIM-66), Servico de Geriatria, Faculdade de Medicina, Hospital das Clinicas HCFMUSP, Universidade de Sao Paulo, Av. Dr. Eneas de Carvalho Aguiar 155, 8° andar, Setor Azul (Clinica Medica), LIM-66, Cerqueira Cesar, Sao Paulo, SP, 05403-000, Brazil
  • Aliberti MJR; Laboratorio de Investigacao Medica em Envelhecimento (LIM-66), Servico de Geriatria, Faculdade de Medicina, Hospital das Clinicas HCFMUSP, Universidade de Sao Paulo, Av. Dr. Eneas de Carvalho Aguiar 155, 8° andar, Setor Azul (Clinica Medica), LIM-66, Cerqueira Cesar, Sao Paulo, SP, 05403-000, Brazil
  • Avelino-Silva TJ; Laboratorio de Investigacao Medica em Envelhecimento (LIM-66), Servico de Geriatria, Faculdade de Medicina, Hospital das Clinicas HCFMUSP, Universidade de Sao Paulo, Av. Dr. Eneas de Carvalho Aguiar 155, 8° andar, Setor Azul (Clinica Medica), LIM-66, Cerqueira Cesar, Sao Paulo, SP, 05403-000, Brazil
  • Apolinario D; Laboratorio de Investigacao Medica em Envelhecimento (LIM-66), Servico de Geriatria, Faculdade de Medicina, Hospital das Clinicas HCFMUSP, Universidade de Sao Paulo, Av. Dr. Eneas de Carvalho Aguiar 155, 8° andar, Setor Azul (Clinica Medica), LIM-66, Cerqueira Cesar, Sao Paulo, SP, 05403-000, Brazil
  • Suemoto CK; Laboratorio de Investigacao Medica em Envelhecimento (LIM-66), Servico de Geriatria, Faculdade de Medicina, Hospital das Clinicas HCFMUSP, Universidade de Sao Paulo, Av. Dr. Eneas de Carvalho Aguiar 155, 8° andar, Setor Azul (Clinica Medica), LIM-66, Cerqueira Cesar, Sao Paulo, SP, 05403-000, Brazil
  • Jacob-Filho W; Laboratorio de Investigacao Medica em Envelhecimento (LIM-66), Servico de Geriatria, Faculdade de Medicina, Hospital das Clinicas HCFMUSP, Universidade de Sao Paulo, Av. Dr. Eneas de Carvalho Aguiar 155, 8° andar, Setor Azul (Clinica Medica), LIM-66, Cerqueira Cesar, Sao Paulo, SP, 05403-000, Brazil
BMC Geriatr ; 20(1): 427, 2020 10 27.
Article em En | MEDLINE | ID: mdl-33109121
BACKGROUND: The demographic changes in Brazil as a result of population aging is one of the fastest in the world. The far-reaching new challenges that come with a large older population are particularly disquieting in low- and middle-income countries (LMICs). Longitudinal studies must be completed in LMICs to investigate the social and biological determinants of aging and the consequences of such demographic changes in their context. Therefore, we designed the Prospective GERiatric Observational (ProGERO) study, a longitudinal study of outpatient older adults in São Paulo, Brazil, to collect data both on aging and chronic diseases, and investigate characteristics associated with adverse outcomes in this population. METHODS: The ProGERO study takes place in a geriatric outpatient clinic in the largest academic medical center in Latin America. We performed baseline health examinations in 2017 and will complete subsequent in-person visits every 3 years when new participants will also be recruited. We will use periodic telephone interviews to collect information on the outcomes of interest between in-person visits. The baseline evaluation included data on demographics, medical history, physical examination, and comprehensive geriatric assessment (CGA; including multimorbidity, medications, social support, functional status, cognition, depressive symptoms, nutritional status, pain assessment, frailty, gait speed, handgrip strength, and chair-stands test). We used a previously validated CGA-based model to rank participants according to mortality risk (low, medium, high). Our selected outcomes were falls, disability, health services utilization (emergency room visits and hospital admissions), institutionalization, and death. We will follow participants for at least 10 years. RESULTS: We included 1336 participants with a mean age of 82 ± 8 years old. Overall, 70% were women, 31% were frail, and 43% had a Charlson comorbidity index score ≥ 3. According to our CGA-based model, the incidence of death in 1 year varied significantly across categories (low-risk = 0.6%; medium-risk = 7.4%; high-risk = 17.5%; P < 0.001). CONCLUSION: The ProGERO study will provide detailed clinical data and explore the late-life trajectories of outpatient older patients during a follow-up period of at least 10 years. Moreover, the study will substantially contribute to new information on the predictors of aging, senescence, and senility, particularly in frail and pre-frail outpatients from an LMIC city.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Força da Mão / Fragilidade Tipo de estudo: Diagnostic_studies / Etiology_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Limite: Aged / Aged80 / Female / Humans / Male País/Região como assunto: America do sul / Brasil Idioma: En Revista: BMC Geriatr Assunto da revista: GERIATRIA Ano de publicação: 2020 Tipo de documento: Article País de afiliação: Brasil País de publicação: Reino Unido

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Força da Mão / Fragilidade Tipo de estudo: Diagnostic_studies / Etiology_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Limite: Aged / Aged80 / Female / Humans / Male País/Região como assunto: America do sul / Brasil Idioma: En Revista: BMC Geriatr Assunto da revista: GERIATRIA Ano de publicação: 2020 Tipo de documento: Article País de afiliação: Brasil País de publicação: Reino Unido