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Seroprevalence of Specific Antibodies against SARS-CoV-2 from Hotspot Communities in the Dominican Republic.
Paulino-Ramirez, Robert; Báez, Amado Alejandro; Vallejo Degaudenzi, Alejandro; Tapia, Leandro.
Afiliação
  • Paulino-Ramirez R; 1Instituto de Medicina Tropical & Salud Global, Universidad Iberoamericana, Santo Domingo, Dominican Republic.
  • Báez AA; 2COVID-19 Emergency Presidential Committee, Santo Domingo, Dominican Republic.
  • Vallejo Degaudenzi A; 2COVID-19 Emergency Presidential Committee, Santo Domingo, Dominican Republic.
  • Tapia L; 3Department of Emergency Medicine, Medical College of Georgia, Augusta, Georgia.
Am J Trop Med Hyg ; 103(6): 2343-2346, 2020 Dec.
Article em En | MEDLINE | ID: mdl-33094710
Seroprevalence surveys are of utmost importance to assess the proportion of a population that has developed antibodies against a newly introduced virus and could therefore potentially exhibit immunologic protection against subsequent infection. This study aims to understand the distribution of IgM and IgG antibodies in the Dominican Republic. We surveyed a total of 12,897 participants between April and June 2020 in 10 provinces of the Dominican Republic. Survey efforts in emerging hotspots yielded a positivity for all participants of anti-SARS-CoV-2 IgM of 3.8% and IgG of 5.4%, indicating that the pathogen was in circulation before the identification of those particular communities as hotspots. We found important age differences between participants who participated in the serological study where a higher mean age is associated IgM positivity and a lower age with IgG positivity. Our results highlight the need for strategies that involve community-based seroprevalence monitoring. These should preclude syndromic case identification. Also, the higher mean age of IgM-positive participants suggests that strategies based on syndromic surveillance could identify hotspots at later phases, based on the number of cases detected at the healthcare center, as such community-based seroprevalence monitoring may be an effective intervention for future outbreaks.
Assuntos

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Imunoglobulina G / Imunoglobulina M / Pandemias / SARS-CoV-2 / COVID-19 / Anticorpos Antivirais Tipo de estudo: Diagnostic_studies / Prognostic_studies / Screening_studies Limite: Adolescent / Adult / Child / Child, preschool / Female / Humans / Infant / Male / Middle aged / Newborn País/Região como assunto: Caribe ingles / Dominica / Republica dominicana Idioma: En Revista: Am J Trop Med Hyg Ano de publicação: 2020 Tipo de documento: Article País de afiliação: República Dominicana País de publicação: Estados Unidos

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Imunoglobulina G / Imunoglobulina M / Pandemias / SARS-CoV-2 / COVID-19 / Anticorpos Antivirais Tipo de estudo: Diagnostic_studies / Prognostic_studies / Screening_studies Limite: Adolescent / Adult / Child / Child, preschool / Female / Humans / Infant / Male / Middle aged / Newborn País/Região como assunto: Caribe ingles / Dominica / Republica dominicana Idioma: En Revista: Am J Trop Med Hyg Ano de publicação: 2020 Tipo de documento: Article País de afiliação: República Dominicana País de publicação: Estados Unidos