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Simulated gastrointestinal digestion of Brazilian açaí seeds affects the content of flavan-3-ol derivatives, and their antioxidant and anti-inflammatory activities.
Melo, Priscilla Siqueira; Massarioli, Adna Prado; Lazarini, Josy Goldoni; Soares, Jackeline Cintra; Franchin, Marcelo; Rosalen, Pedro Luiz; Alencar, Severino Matias de.
Afiliação
  • Melo PS; Department of Agri-food Industry, Food and Nutrition, 'Luiz de Queiroz' College of Agriculture, University of São Paulo, Pádua Dias Avenue, P.O. Box. 9, 13418-900, Piracicaba, SP, Brazil.
  • Massarioli AP; Center of Nature Sciences, Lagoa do Sino Campus, Federal University of São Carlos (UFSCar), Lauri Simões de Barros Highway, Km 12, SP-189, 18290-000, Buri, SP, Brazil.
  • Lazarini JG; Department of Agri-food Industry, Food and Nutrition, 'Luiz de Queiroz' College of Agriculture, University of São Paulo, Pádua Dias Avenue, P.O. Box. 9, 13418-900, Piracicaba, SP, Brazil.
  • Soares JC; Piracicaba Dental School, Department of Physiological Sciences, University of Campinas, 901 Limeira Avenue, 13414-903, Piracicaba, SP, Brazil.
  • Franchin M; Department of Agri-food Industry, Food and Nutrition, 'Luiz de Queiroz' College of Agriculture, University of São Paulo, Pádua Dias Avenue, P.O. Box. 9, 13418-900, Piracicaba, SP, Brazil.
  • Rosalen PL; Piracicaba Dental School, Department of Physiological Sciences, University of Campinas, 901 Limeira Avenue, 13414-903, Piracicaba, SP, Brazil.
  • Alencar SM; Piracicaba Dental School, Department of Physiological Sciences, University of Campinas, 901 Limeira Avenue, 13414-903, Piracicaba, SP, Brazil.
Heliyon ; 6(10): e05214, 2020 Oct.
Article em En | MEDLINE | ID: mdl-33088966
Açaí seeds (Euterpe oleracea Mart.) are the major residue generated during industrial extraction of açaí fruit pulp - a popular and typical Amazon fruit rich in bioactive compounds and nutrients. In this study, we investigated the bioaccessibility of an açaí seed extract using an in vitro simulated gastrointestinal digestion model. Catechin, epicatechin and procyanidins B1 and B2 were identified and quantified in the açaí seed extract and monitored by HPLC-DAD through the digestion phases. Bioaccessibility of these flavan-3-ols and deactivation of reactive oxygen species decreased after the intestinal phase, except for peroxyl radical (ROO●). RAW 264.7 macrophages treated either with the digested or undigested açaí seed extract showed reduced NF-κB activation and TNF-α levels, even following gastrointestinal digestion. Thus, the ROO● scavenging capacity and anti-inflammatory activity of the extract were found to be still remarkable after digestion, suggesting that açaí seeds could be explored as a source of bioactive compounds for functional foods, cosmetic or pharmaceutical purposes.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE País/Região como assunto: America do sul / Brasil Idioma: En Revista: Heliyon Ano de publicação: 2020 Tipo de documento: Article País de afiliação: Brasil País de publicação: Reino Unido
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE País/Região como assunto: America do sul / Brasil Idioma: En Revista: Heliyon Ano de publicação: 2020 Tipo de documento: Article País de afiliação: Brasil País de publicação: Reino Unido