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A mechanistic model of the neural entropy increase elicited by psychedelic drugs.
Herzog, Rubén; Mediano, Pedro A M; Rosas, Fernando E; Carhart-Harris, Robin; Perl, Yonatan Sanz; Tagliazucchi, Enzo; Cofre, Rodrigo.
Afiliação
  • Herzog R; Centro Interdisciplinario de Neurociencia de Valparaíso, Universidad de Valparaíso, Pje Harrington 287, 2360103, Valparaiso, Chile. rubenherzog@ug.uchile.cl.
  • Mediano PAM; Department of Psychology, University of Cambridge, Cambridge, CB2 3EB, UK.
  • Rosas FE; Department of Brain Science, Centre for Psychedelic Research, Imperial College London, London, SW7 2DD, UK.
  • Carhart-Harris R; Data Science Institute, Imperial College London, London, SW7 2AZ, UK.
  • Perl YS; Centre for Complexity Science, Imperial College London, London, SW7 2AZ, UK.
  • Tagliazucchi E; Department of Brain Science, Centre for Psychedelic Research, Imperial College London, London, SW7 2DD, UK.
  • Cofre R; Buenos Aires Physics Institute and Physics Department, University of Buenos Aires, Buenos Aires, Argentina.
Sci Rep ; 10(1): 17725, 2020 10 20.
Article em En | MEDLINE | ID: mdl-33082424
Psychedelic drugs, including lysergic acid diethylamide and other agonists of the serotonin 2A receptor (5HT2A-R), induce drastic changes in subjective experience, and provide a unique opportunity to study the neurobiological basis of consciousness. One of the most notable neurophysiological signatures of psychedelics, increased entropy in spontaneous neural activity, is thought to be of relevance to the psychedelic experience, mediating both acute alterations in consciousness and long-term effects. However, no clear mechanistic explanation for this entropy increase has been put forward so far. We sought to do this here by building upon a recent whole-brain model of serotonergic neuromodulation, to study the entropic effects of 5HT2A-R activation. Our results reproduce the overall entropy increase observed in previous experiments in vivo, providing the first model-based explanation for this phenomenon. We also found that entropy changes were not uniform across the brain: entropy increased in some regions and decreased in others, suggesting a topographical reconfiguration mediated by 5HT2A-R activation. Interestingly, at the whole-brain level, this reconfiguration was not well explained by 5HT2A-R density, but related closely to the topological properties of the brain's anatomical connectivity. These results help us understand the mechanisms underlying the psychedelic state and, more generally, the pharmacological modulation of whole-brain activity.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Encéfalo / Estado de Consciência / Agonistas do Receptor 5-HT2 de Serotonina / Alucinógenos / Dietilamida do Ácido Lisérgico / Neurônios Limite: Humans Idioma: En Revista: Sci Rep Ano de publicação: 2020 Tipo de documento: Article País de afiliação: Chile País de publicação: Reino Unido
Texto completo
Adicionar na Minha BVS
Imprimir
XML
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Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Encéfalo / Estado de Consciência / Agonistas do Receptor 5-HT2 de Serotonina / Alucinógenos / Dietilamida do Ácido Lisérgico / Neurônios Limite: Humans Idioma: En Revista: Sci Rep Ano de publicação: 2020 Tipo de documento: Article País de afiliação: Chile País de publicação: Reino Unido