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Comparison of Clinical and Epidemiologic Characteristics of Young Febrile Infants with and without Severe Acute Respiratory Syndrome Coronavirus-2 Infection.
Leibowitz, Jill; Krief, William; Barone, Stephen; Williamson, Kristy A; Goenka, Pratichi K; Rai, Shipra; Moriarty, Shannon; Baodhankar, Prachi; Rubin, Lorry G.
Afiliação
  • Leibowitz J; Department of Pediatrics, Cohen Children's Medical Center, Northwell Health, New Hyde Park, NY; Donald and Barbara Zucker School of Medicine at Hofstra/Northwell, Northwell Health, Hempstead, NY. Electronic address: Jleibowitz@northwell.edu.
  • Krief W; Department of Pediatrics, Cohen Children's Medical Center, Northwell Health, New Hyde Park, NY; Donald and Barbara Zucker School of Medicine at Hofstra/Northwell, Northwell Health, Hempstead, NY.
  • Barone S; Department of Pediatrics, Cohen Children's Medical Center, Northwell Health, New Hyde Park, NY; Donald and Barbara Zucker School of Medicine at Hofstra/Northwell, Northwell Health, Hempstead, NY.
  • Williamson KA; Department of Pediatrics, Cohen Children's Medical Center, Northwell Health, New Hyde Park, NY; Donald and Barbara Zucker School of Medicine at Hofstra/Northwell, Northwell Health, Hempstead, NY.
  • Goenka PK; Department of Pediatrics, Cohen Children's Medical Center, Northwell Health, New Hyde Park, NY; Donald and Barbara Zucker School of Medicine at Hofstra/Northwell, Northwell Health, Hempstead, NY.
  • Rai S; Department of Pediatrics, Cohen Children's Medical Center, Northwell Health, New Hyde Park, NY.
  • Moriarty S; Department of Pediatrics, Cohen Children's Medical Center, Northwell Health, New Hyde Park, NY.
  • Baodhankar P; Department of Pediatrics, Cohen Children's Medical Center, Northwell Health, New Hyde Park, NY.
  • Rubin LG; Department of Pediatrics, Cohen Children's Medical Center, Northwell Health, New Hyde Park, NY; Donald and Barbara Zucker School of Medicine at Hofstra/Northwell, Northwell Health, Hempstead, NY.
J Pediatr ; 229: 41-47.e1, 2021 Feb.
Article em En | MEDLINE | ID: mdl-33045235
OBJECTIVE: To determine features that distinguish febrile young infants with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. STUDY DESIGN: Retrospective single-center study included febrile infants <57 days of age evaluated in the emergency department of Cohen Children's Medical Center of Northwell Health, New Hyde Park, New York, from March 1 to April 30 of 2018, 2019, and 2020. Sociodemographic and clinical features were compared between those seen during the 2020 coronavirus disease-2019 pandemic and previous years, as well as between infants with SARS-CoV-2 infection and infants without SARS-CoV-2 infection (SARS-CoV-2 negative or evaluated during 2018 and 2019). RESULTS: In all, 124 febrile infants <57 days of age were identified; 38 during the 2-month study period in 2018, 33 in 2019, and 53 in 2020. During 2020, fewer febrile infants had a serious bacterial infection or a positive respiratory viral panel than in prior years (6% vs 21% [P = .02]; 15% vs 53% [P < .001], respectively). SARS-CoV-2 was the most frequent pathogen detected in 2020; of 30 infants tested, 20 tested positive. Infants with SARS-CoV-2 were more likely to identify as Hispanic (P = .004), have public insurance or be uninsured (P = .01), exhibited lethargy (P = .02), had feeding difficulties (P = .002), and had lower white blood cell (P = .001), neutrophil (P < .001), and lymphocyte counts (P = .005) than the 81 infants without SARS-CoV-2 infection. None of the infants with SARS-CoV-2 had concurrent serious bacterial infection or detection of another virus. Overall, disease in infants with SARS-CoV-2 was mild. CONCLUSIONS: During the peak of the pandemic, SARS-CoV-2 was the predominant pathogen among febrile infants. Socioeconomic, historical, and laboratory features differed significantly between infants infected or not infected with SARS-CoV-2. None of the 20 infants with SARS-CoV-2 infection had an identified coviral or serious bacterial infection.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Febre / COVID-19 Tipo de estudo: Diagnostic_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Limite: Female / Humans / Infant / Male / Newborn País/Região como assunto: America do norte Idioma: En Revista: J Pediatr Ano de publicação: 2021 Tipo de documento: Article País de publicação: Estados Unidos

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Febre / COVID-19 Tipo de estudo: Diagnostic_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Limite: Female / Humans / Infant / Male / Newborn País/Região como assunto: America do norte Idioma: En Revista: J Pediatr Ano de publicação: 2021 Tipo de documento: Article País de publicação: Estados Unidos