Immune-mediated necrotising myopathy in asymptomatic patients with high creatine kinase.
BMJ Case Rep
; 13(10)2020 Oct 08.
Article
em En
| MEDLINE
| ID: mdl-33033004
Subacute symmetrical proximal muscle weakness and persistent elevated creatine kinase levels are typical of immune-mediated necrotising myopathy (IMNM). These conditions are accompanied by copious myofibre necrosis, degeneration and regeneration with minimal to no inflammation on muscle biopsy. We report two cases (case 1 and case 2) of asymptomatic IMNM from different families with hyperCKaemia associated with positive anti-signal recognition particle (SRP) and anti-3-hydroxy-3-methylglutaryl-coenzyme A reductase (HMGCR) antibodies, respectively, and we also reviewed the literature. There are only a few previous descriptions of patients with asymptomatic IMNM.The disease onset could be insidious and lead to delayed diagnosis and treatment. We recommend testing for the anti-HMGCR and anti-SRP antibodies in patients with idiopathic hyperCKaemia because they could show no symptoms of this disorder.
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Autoanticorpos
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Imunoglobulinas Intravenosas
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Partícula de Reconhecimento de Sinal
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Creatina Quinase
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Hidroximetilglutaril-CoA Redutases
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Miosite
Tipo de estudo:
Diagnostic_studies
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Etiology_studies
Limite:
Female
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Humans
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Male
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Middle aged
Idioma:
En
Revista:
BMJ Case Rep
Ano de publicação:
2020
Tipo de documento:
Article
País de afiliação:
Brasil
País de publicação:
Reino Unido