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Fetal programming by high-fat diet promoted the decreased of the prostate in adult Wistar albino rats.
Campos-Silva, Pamella; Fernandes, Angelo; Costa, Waldemar; Sampaio, Francisco Jose; Gregorio, Bianca.
Afiliação
  • Campos-Silva P; Urogenital Research Unit, Biomedical Center, Department of Anatomy, State University of Rio de Janeiro, Av. 28 de setembro 87 (fds), 20551-030 Rio de Janeiro, RJ, Brazil.
  • Fernandes A; Urogenital Research Unit, Biomedical Center, Department of Anatomy, State University of Rio de Janeiro, Av. 28 de setembro 87 (fds), 20551-030 Rio de Janeiro, RJ, Brazil.
  • Costa W; Urogenital Research Unit, Biomedical Center, Department of Anatomy, State University of Rio de Janeiro, Av. 28 de setembro 87 (fds), 20551-030 Rio de Janeiro, RJ, Brazil.
  • Sampaio FJ; Urogenital Research Unit, Biomedical Center, Department of Anatomy, State University of Rio de Janeiro, Av. 28 de setembro 87 (fds), 20551-030 Rio de Janeiro, RJ, Brazil.
  • Gregorio B; Urogenital Research Unit, Biomedical Center, Department of Anatomy, State University of Rio de Janeiro, Av. 28 de setembro 87 (fds), 20551-030 Rio de Janeiro, RJ, Brazil. Electronic address: biancamgregorio.uerj@gmail.com.
Mech Dev ; 164: 103649, 2020 12.
Article em En | MEDLINE | ID: mdl-33022371
We investigated the effect of a high-fat diet on body metabolism and ventral prostate morphology in 4-months-old offspring. The mother was fed with a control (C) or a high-fat (HF) diet during gestation and lactation. At weaning, the offspring diet remained the same (C/C, n = 8; HF/HF, n = 8) or it was switched (C/HF, n = 8; HF/C, n = 9). Biometry, blood pressure (BP), glucose, lipid metabolism and ventral prostate were evaluated. Triacylglycerol of HF/C increased, and the C/HF group had decreased HDL-c levels (P = 0.0005 and P = 0.0100, respectively). All groups on the HF diet presented hyperglycemia (P = 0.0064). Serum testosterone diminished in the C/HF group (P = 0.0218). The HF diet, regardless of the period, reduced prostatic acinar area (P < 0.0001). The epithelium height was smaller in HF/C and HF/HF groups compared with C/C and C/HF (P < 0.0001), and the volume density of epithelium was lower in HF/C group compared with the C/C and C/HF (P = 0.0024). The volume density of smooth muscle cells diminished in C/HF and HF/C (P = 0.0013), and the volume density of connective tissue was reduced in HF/C and HF/HF (P < 0.0001). High-fat diet intake during prenatal and postnatal life leads to prostatic atrophy, which may impair prostate secretory activity and contractility, and thus disturb reproductive function in adulthood.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Próstata / Fenômenos Fisiológicos da Nutrição Materna / Desenvolvimento Fetal / Dieta Hiperlipídica Limite: Animals Idioma: En Revista: Mech Dev Assunto da revista: EMBRIOLOGIA Ano de publicação: 2020 Tipo de documento: Article País de afiliação: Brasil País de publicação: Irlanda
Texto completo
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XML
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Próstata / Fenômenos Fisiológicos da Nutrição Materna / Desenvolvimento Fetal / Dieta Hiperlipídica Limite: Animals Idioma: En Revista: Mech Dev Assunto da revista: EMBRIOLOGIA Ano de publicação: 2020 Tipo de documento: Article País de afiliação: Brasil País de publicação: Irlanda