Immunopathology and modulation induced by hookworms: From understanding to intervention.
Parasite Immunol
; 43(2): e12798, 2021 02.
Article
em En
| MEDLINE
| ID: mdl-33012113
Hookworm infection is considered the most prevalent human soil-transmitted helminth infection affecting approximately 500 million people and accounting for 3.2 million disability-adjusted life years lost annually. As with many other neglected tropical diseases, no international surveillance mechanisms that show accurate data on the prevalence of hookworm infection are in place, thus hindering strategies to control parasite transmission. In this review, we unravel the current knowledge in immunopathology and immunoregulation of hookworm infection and present discoveries in drug therapies based on the capability of hookworms to regulate inflammation to treat allergic, inflammatory and metabolic diseases. Additionally, we highlight potential vaccine development and treatments and propose avenues for further inquiry.
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Ancylostomatoidea
/
Infecções por Uncinaria
Tipo de estudo:
Prevalence_studies
Aspecto:
Patient_preference
Limite:
Animals
/
Humans
/
Male
Idioma:
En
Revista:
Parasite Immunol
Ano de publicação:
2021
Tipo de documento:
Article
País de afiliação:
Brasil
País de publicação:
Reino Unido