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Metabolic landscape of oral squamous cell carcinoma.
Vitório, Jéssica Gardone; Duarte-Andrade, Filipe Fideles; Dos Santos Fontes Pereira, Thaís; Fonseca, Felipe Paiva; Amorim, Larissa Stefhanne Damasceno; Martins-Chaves, Roberta Rayra; Gomes, Carolina Cavaliéri; Canuto, Gisele André Baptista; Gomez, Ricardo Santiago.
Afiliação
  • Vitório JG; Department of Oral Surgery and Pathology, School of Dentistry, Universidade Federal de Minas Gerais (UFMG), Av. Presidente Antônio Carlos, Belo Horizonte, Minas Gerais, 6627, 31270-901, Brazil.
  • Duarte-Andrade FF; Department of Oral Surgery and Pathology, School of Dentistry, Universidade Federal de Minas Gerais (UFMG), Av. Presidente Antônio Carlos, Belo Horizonte, Minas Gerais, 6627, 31270-901, Brazil.
  • Dos Santos Fontes Pereira T; Department of Oral Surgery and Pathology, School of Dentistry, Universidade Federal de Minas Gerais (UFMG), Av. Presidente Antônio Carlos, Belo Horizonte, Minas Gerais, 6627, 31270-901, Brazil.
  • Fonseca FP; Department of Oral Surgery and Pathology, School of Dentistry, Universidade Federal de Minas Gerais (UFMG), Av. Presidente Antônio Carlos, Belo Horizonte, Minas Gerais, 6627, 31270-901, Brazil.
  • Amorim LSD; Department of Oral Surgery and Pathology, School of Dentistry, Universidade Federal de Minas Gerais (UFMG), Av. Presidente Antônio Carlos, Belo Horizonte, Minas Gerais, 6627, 31270-901, Brazil.
  • Martins-Chaves RR; Department of Oral Surgery and Pathology, School of Dentistry, Universidade Federal de Minas Gerais (UFMG), Av. Presidente Antônio Carlos, Belo Horizonte, Minas Gerais, 6627, 31270-901, Brazil.
  • Gomes CC; Department of Pathology, Biological Sciences Institute, Universidade Federal de Minas Gerais (UFMG), Belo Horizonte, Minas Gerais, Brazil.
  • Canuto GAB; Department of Analytical Chemistry, Institute of Chemistry, Universidade Federal da Bahia (UFBA), Salvador, Bahia, Brazil.
  • Gomez RS; Department of Oral Surgery and Pathology, School of Dentistry, Universidade Federal de Minas Gerais (UFMG), Av. Presidente Antônio Carlos, Belo Horizonte, Minas Gerais, 6627, 31270-901, Brazil. rsgomez@ufmg.br.
Metabolomics ; 16(10): 105, 2020 09 30.
Article em En | MEDLINE | ID: mdl-33000429
BACKGROUND: Head and neck cancers are the seventh most common type of cancer worldwide, with almost half of the cases affecting the oral cavity. Oral squamous cell carcinoma (OSCC) is the most common form of oral cancer, showing poor prognosis and high mortality. OSCC molecular pathogenesis is complex, resulting from a wide range of events that involve the interplay between genetic mutations and altered levels of transcripts, proteins, and metabolites. Metabolomics is a recently developed sub-area of omics sciences focused on the comprehensive analysis of small molecules involved in several biological pathways by high throughput technologies. AIM OF REVIEW: This review summarizes and evaluates studies focused on the metabolomics analysis of OSCC and oral premalignant disorders to better interpret the complex process of oral carcinogenesis. Additionally, the metabolic biomarkers signatures identified so far are also included. Moreover, we discuss the limitations of these studies and make suggestions for future investigations. KEY SCIENTIFIC CONCEPTS: Although many questions about the metabolic features of OSCC have already been answered in metabolomic studies, further validation and optimization are still required to translate these findings into clinical applications.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Neoplasias Bucais / Carcinoma de Células Escamosas de Cabeça e Pescoço / Neoplasias de Cabeça e Pescoço Tipo de estudo: Prognostic_studies Limite: Humans Idioma: En Revista: Metabolomics Ano de publicação: 2020 Tipo de documento: Article País de afiliação: Brasil País de publicação: Estados Unidos
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Neoplasias Bucais / Carcinoma de Células Escamosas de Cabeça e Pescoço / Neoplasias de Cabeça e Pescoço Tipo de estudo: Prognostic_studies Limite: Humans Idioma: En Revista: Metabolomics Ano de publicação: 2020 Tipo de documento: Article País de afiliação: Brasil País de publicação: Estados Unidos