Antiparasitic activities of novel pyrimidine N-acylhydrazone hybrids.
Drug Dev Res
; 82(2): 230-240, 2021 04.
Article
em En
| MEDLINE
| ID: mdl-32996619
In this article, a series of 29 new pyrimidine N-acylhydrazone hybrids were synthesized and evaluated in vitro against Leishmania amazonensis and Trypanosoma cruzi protozoa that cause the neglected diseases cutaneous leishmaniasis and Chagas disease, respectively. Eight of the target compounds showed significant antiprotozoal activities with IC50 values in 4.3-33.6 µM range. The more active compound 4f exhibited selectivity index greater than 15 and drug-like properties based on Lipinski's rule.
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Pirimidinas
/
Trypanosoma cruzi
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Leishmania braziliensis
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Hidrazonas
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Antiparasitários
Limite:
Animals
/
Humans
Idioma:
En
Revista:
Drug Dev Res
Ano de publicação:
2021
Tipo de documento:
Article
País de afiliação:
Brasil
País de publicação:
Estados Unidos