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Periodontal Attachment Loss in Children with Amegakaryocytic Purpura: Case Reports of Two Male Siblings.
Ballardin, Bárbara Soldatelli; Rodrigues, Suelen aCroline; Feres, Magda; Torres-Pereira, Cassius Carvalho; Soares, Geisla Mary Silva.
Afiliação
  • Ballardin BS; Multiprofessional Residency Program in Oncology and Hematology, Hospital de Clínicas, Federal University of Parana, Curitiba, Brazil.
  • Rodrigues SA; Multiprofessional Residency Program in Oncology and Hematology, Hospital de Clínicas, Federal University of Parana, Curitiba, Brazil.
  • Feres M; Dental Research Division, Department of Periodontology, Guarulhos University, Guarulhos, Brazil.
  • Torres-Pereira CC; 1Multiprofessional Residency Program in Oncology and Hematology, Hospital de Clínicas, Federal University of Parana, Curitiba, Brazil; and Post Graduate Program in Dentistry, Department of Stomatology, Federal University of Parana, Curitiba, Brazil.
  • Soares GMS; Multiprofessional Residency Program in Oncology and Hematology, Hospital de Clínicas, Federal University of Parana, Curitiba, Brazil; and Post Graduate Program in Dentistry, Department of Stomatology, Federal University of Parana, Curitiba, Brazil. E-mail: geisla.soares@ufpr.br.
J Int Acad Periodontol ; 22(4): 182-186, 2020 10 01.
Article em En | MEDLINE | ID: mdl-32980831
AIMS: To report the periodontal condition of two siblings (ages 2 and 4) diagnosed with congenital Amegakaryocytic Purpura (AP), who underwent allogeneic hematopoietic stem cell transplant (HSCT) and developed graft-versus-host disease (GVHD) with oral manifestations. METHODS: Clinical history was obtained through physical examination and medical records. Patients received clinical and microbiological assessment at 2 months post-HSCT, when they started to show signs and symptoms of GVHD and were monitored at 8/15-months post-transplant. They were treated by means of prophylaxis and oral hygiene instruction. Two supragingival biofilm samples were collected from each patient and analyzed by Checkerboard DNA-DNA hybridization. RESULTS: Patients developed severe periodontal clinical attachment loss (CAL) in deciduous dentition associated with recession of the periodontal tissues. They also presented GVHD lesions in the oral mucosa, lips and tongue. Caries lesions, gingivitis, and heavy biofilm deposits were identified. The microbiological profile of biofilm samples presented high levels and proportions of periodontal pathogens, such as Aggregatibacter actinomycetemcomitans. CONCLUSION: The cases presented suggested that severe periodontal CAL in children with AP may be an atypical manifestation associated with AP and/or GVHD, which may be aggravated by the presence of a dysbiotic biofilm containing periodontal pathogens, especially A. actinomycetemcomitans.
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Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Doenças Periodontais / Púrpura Tipo de estudo: Prognostic_studies Limite: Child / Child, preschool / Humans / Male Idioma: En Revista: J Int Acad Periodontol Assunto da revista: ODONTOLOGIA Ano de publicação: 2020 Tipo de documento: Article País de afiliação: Brasil País de publicação: Reino Unido
Buscar no Google
Adicionar na Minha BVS
Imprimir
XML
PubMed Links

Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Doenças Periodontais / Púrpura Tipo de estudo: Prognostic_studies Limite: Child / Child, preschool / Humans / Male Idioma: En Revista: J Int Acad Periodontol Assunto da revista: ODONTOLOGIA Ano de publicação: 2020 Tipo de documento: Article País de afiliação: Brasil País de publicação: Reino Unido