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The impact that ß-citronellol isomers have on the biofilm formation of Candida yeasts.
Silva, Daniele de Figueredo; Cordeiro, Laísa Vilar; Figueiredo, Pedro Thiago Ramalho; Diniz-Neto, Hermes; Souza, Helivaldo Diógenes da Silva; Lima, Edeltrudes de Oliveira.
Afiliação
  • Silva DF; Post-Graduation Program in Natural Products and Bioactive Synthetics, Department of Pharmaceutical Sciences, Federal University of Paraíba, João Pessoa, Paraíba, Brazil.
  • Cordeiro LV; Post-Graduation Program in Natural Products and Bioactive Synthetics, Department of Pharmaceutical Sciences, Federal University of Paraíba, João Pessoa, Paraíba, Brazil.
  • Figueiredo PTR; Post-Graduation Program in Natural Products and Bioactive Synthetics, Department of Pharmaceutical Sciences, Federal University of Paraíba, João Pessoa, Paraíba, Brazil.
  • Diniz-Neto H; Post-Graduation Program in Natural Products and Bioactive Synthetics, Department of Pharmaceutical Sciences, Federal University of Paraíba, João Pessoa, Paraíba, Brazil.
  • Souza HDDS; Department of Chemistry, Federal University of Paraíba, João Pessoa, Paraíba, Brazil.
  • Lima EO; Post-Graduation Program in Natural Products and Bioactive Synthetics, Department of Pharmaceutical Sciences, Federal University of Paraíba, João Pessoa, Paraíba, Brazil.
Nat Prod Res ; 35(24): 6002-6006, 2021 Dec.
Article em En | MEDLINE | ID: mdl-32975125
Infections associated with biofilms developed by Candida spp. are becoming a great problem due to its resistance against the immune response of the host and the action of antifungal agents. Hence, finding substances that can inhibit the development of biofilms increases the likelihood that these compounds one day can become good antifungals applied in the clinic. The aim of this study was to evaluate the effect of ß-citronellol enantiomers on the biofilm formation by Candida albicans and Candida tropicalis isolated from bloodstream infections. Inhibition was evaluated by reading microplates treated with different concentrations of R-(+)-ß-citronellol, S-(-)-ß-citronellol and amphotericin B, compared to negative control, in spectrophotometer at 590 nm. All tested concentrations of ß-citronellol enantiomers inhibited the biofilm formation of Candida. However, it is still necessary to evaluate the behavior of these isomers on mature biofilms, so that they can become more viable as antifungal therapeutical agents.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Candida / Antifúngicos Idioma: En Revista: Nat Prod Res Ano de publicação: 2021 Tipo de documento: Article País de afiliação: Brasil País de publicação: Reino Unido
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Candida / Antifúngicos Idioma: En Revista: Nat Prod Res Ano de publicação: 2021 Tipo de documento: Article País de afiliação: Brasil País de publicação: Reino Unido