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Meconium microbiome and its relation to neonatal growth and head circumference catch-up in preterm infants.
Terrazzan Nutricionist, Ana Carolina; Procianoy, Renato S; Roesch, Luiz Fernando Wurdig; Corso, Andrea Lúcia; Dobbler, Priscila Thiago; Silveira, Rita C.
Afiliação
  • Terrazzan Nutricionist AC; Postgraduate Program in Child and Adolescent Health-PPGSCA, Federal University of Rio Grande do Sul-UFRGS, Porto Alegre, Brazil.
  • Procianoy RS; Neonatal Intensive Care Unit Hospital de Clínicas de Porto Alegre, RS, Porto Alegre, Brazil.
  • Roesch LFW; Interdisciplinary Center for Biotechnology Research-CIP-Biotec Federal University of Pampa, São Gabriel, Rio Grande do Sul, Brazil.
  • Corso AL; Neonatal Intensive Care Unit Hospital de Clínicas de Porto Alegre, RS, Porto Alegre, Brazil.
  • Dobbler PT; Interdisciplinary Center for Biotechnology Research-CIP-Biotec Federal University of Pampa, São Gabriel, Rio Grande do Sul, Brazil.
  • Silveira RC; Postgraduate Program in Child and Adolescent Health-PPGSCA, Federal University of Rio Grande do Sul-UFRGS, Porto Alegre, Brazil.
PLoS One ; 15(9): e0238632, 2020.
Article em En | MEDLINE | ID: mdl-32956415
The purpose was identify an association between meconium microbiome, extra-uterine growth restriction, and head circumference catch-up. MATERIALS AND METHODS: Prospective study with preterm infants born <33 weeks gestational age (GA), admitted at Neonatal Unit and attending the Follow-Up Preterm Program of a tertiary hospital. Excluded out born infants; presence of congenital malformations or genetic syndromes; congenital infections; HIV-positive mothers; and newborns whose parents or legal guardians did not authorize participation. Approved by the institution's ethics committee. Conducted 16S rRNA sequencing using PGM Ion Torrent meconium samples for microbiota analysis. RESULTS: Included 63 newborns, GA 30±2.3 weeks, mean weight 1375.80±462.6 grams, 68.3% adequate weight for GA at birth. Polynucleobacter (p = 0.0163), Gp1 (p = 0.018), and Prevotella (p = 0.038) appeared in greater abundance in meconium of preterm infants with adequate birth weight for GA. Thirty (47.6%) children reached head circumference catch-up before 6 months CA and 33 (52.4%) after 6 months CA. Salmonella (p<0.001), Flavobacterium (p = 0.026), and Burkholderia (p = 0.026) were found to be more abundant in meconium in the group of newborns who achieved catch-up prior to 6th month CA. CONCLUSION: Meconium microbiome abundance was related to adequacy of weight for GA. Meconium microbiome differs between children who achieve head circumference catch-up by the 6th month of corrected age or after this period.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Recém-Nascido Prematuro / Cefalometria / Microbiota / Mecônio Tipo de estudo: Observational_studies / Prognostic_studies / Risk_factors_studies Aspecto: Ethics Limite: Adult / Female / Humans / Male / Newborn Idioma: En Revista: PLoS One Assunto da revista: CIENCIA / MEDICINA Ano de publicação: 2020 Tipo de documento: Article País de afiliação: Brasil País de publicação: Estados Unidos
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Recém-Nascido Prematuro / Cefalometria / Microbiota / Mecônio Tipo de estudo: Observational_studies / Prognostic_studies / Risk_factors_studies Aspecto: Ethics Limite: Adult / Female / Humans / Male / Newborn Idioma: En Revista: PLoS One Assunto da revista: CIENCIA / MEDICINA Ano de publicação: 2020 Tipo de documento: Article País de afiliação: Brasil País de publicação: Estados Unidos