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Antileishmanial activity of a new chloroquine analog in an animal model of Leishmania panamensis infection.
Herrera, Lizzi; Llanes, Alejandro; Álvarez, Jennifer; Degracia, Kissy; Restrepo, Carlos M; Rivera, Rene; Stephens, David E; Dang, Hang T; Larionov, Oleg V; Lleonart, Ricardo; Fernández, Patricia L.
Afiliação
  • Herrera L; Centro de Biología Celular y Molecular de Enfermedades, Instituto de Investigaciones Científicas y Servicios de Alta Tecnología (INDICASAT AIP), Edificio 208, Ciudad del Saber, Apartado 0843-01103, Panama, 0801, Panama; Department of Biotechnology, Acharya Nagarjuna University, Nagarjuna Nagar, Gunt
  • Llanes A; Centro de Biología Celular y Molecular de Enfermedades, Instituto de Investigaciones Científicas y Servicios de Alta Tecnología (INDICASAT AIP), Edificio 208, Ciudad del Saber, Apartado 0843-01103, Panama, 0801, Panama; Department of Biotechnology, Acharya Nagarjuna University, Nagarjuna Nagar, Gunt
  • Álvarez J; Escuela de Biología, Facultad de Ciencias Naturales, Exactas y Tecnología, Universidad de Panamá. Panama, 0801, Panama.
  • Degracia K; Escuela de Biotecnología, Facultad de Ciencias de la Salud Dr. William C. Gorgas, Universidad Latina de Panama, 0801, Panama.
  • Restrepo CM; Centro de Biología Celular y Molecular de Enfermedades, Instituto de Investigaciones Científicas y Servicios de Alta Tecnología (INDICASAT AIP), Edificio 208, Ciudad del Saber, Apartado 0843-01103, Panama, 0801, Panama.
  • Rivera R; Centro de Biología Celular y Molecular de Enfermedades, Instituto de Investigaciones Científicas y Servicios de Alta Tecnología (INDICASAT AIP), Edificio 208, Ciudad del Saber, Apartado 0843-01103, Panama, 0801, Panama.
  • Stephens DE; Department of Chemistry, The University of Texas at San Antonio, San Antonio, TX, 78249, United States.
  • Dang HT; Department of Chemistry, The University of Texas at San Antonio, San Antonio, TX, 78249, United States.
  • Larionov OV; Department of Chemistry, The University of Texas at San Antonio, San Antonio, TX, 78249, United States.
  • Lleonart R; Centro de Biología Celular y Molecular de Enfermedades, Instituto de Investigaciones Científicas y Servicios de Alta Tecnología (INDICASAT AIP), Edificio 208, Ciudad del Saber, Apartado 0843-01103, Panama, 0801, Panama.
  • Fernández PL; Centro de Biología Celular y Molecular de Enfermedades, Instituto de Investigaciones Científicas y Servicios de Alta Tecnología (INDICASAT AIP), Edificio 208, Ciudad del Saber, Apartado 0843-01103, Panama, 0801, Panama. Electronic address: pllanes@indicasat.org.pa.
Int J Parasitol Drugs Drug Resist ; 14: 56-61, 2020 12.
Article em En | MEDLINE | ID: mdl-32950020
Leishmania panamensis is a relevant causative agent of tegumentary leishmaniasis in several Latin American countries. Available antileishmanial drugs have several limitations including relatively high toxicity, difficult administration, high production costs and the emergence of resistance in circulating strains. Therefore, the identification of new molecules as potential therapeutics for leishmaniasis is of great relevance. Here, we developed a murine model of L. panamensis infection and evaluated the effect of a new compound in vivo. After treatment of animals with the compound, we observed a significant reduction of inflammation and parasite load at the inoculation site, in a dose-dependent manner. We observed a reduction in IL-10 production by popliteal lymph nodes cells of infected mice. These results pave the way for future evaluation of this compound as a potential antileishmanial drug or as a suitable scaffold for lead optimization strategies.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Leishmaniose / Leishmania / Antiprotozoários Limite: Animals País/Região como assunto: America central / Panama Idioma: En Revista: Int J Parasitol Drugs Drug Resist Ano de publicação: 2020 Tipo de documento: Article País de publicação: Holanda
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Leishmaniose / Leishmania / Antiprotozoários Limite: Animals País/Região como assunto: America central / Panama Idioma: En Revista: Int J Parasitol Drugs Drug Resist Ano de publicação: 2020 Tipo de documento: Article País de publicação: Holanda