Your browser doesn't support javascript.
loading
The effect of nitric oxide, endothelial nitric oxide synthetase, and asymmetric dimethylarginine in hemorrhoidal disease.
Gokce, Aylin Hande; Gokce, Feridun Suat; Durmus, Sinem; Hajiyeva, Ramila; Ersoz, Feyzullah; Gelisgen, Remise; Uzun, Hafize.
Afiliação
  • Gokce AH; . Assistant Professor. Department of General Surgery, Istanbul Atlas University Faculty of Medicine, Istanbul, Turkey.
  • Gokce FS; . Department of General Surgery, Balikli Rum Hospital, Istanbul, Turkey.
  • Durmus S; . Department of Medical Biochemistry, Cerrahpasa Faculty of Medicine, Istanbul University-Cerrahpasa, Istanbul, Turkey.
  • Hajiyeva R; . Assistant Doctor. Department of Medical Biochemistry, Cerrahpasa Faculty of Medicine, Istanbul University-Cerrahpasa, Istanbul, Turkey.
  • Ersoz F; . Associate Professor. Department of General Surgery. Istanbul Training Research Hospital, Istanbul, Turkey.
  • Gelisgen R; . Professor Doctor. Department of Medical Biochemistry, Cerrahpasa Faculty of Medicine, Istanbul University-Cerrahpasa, Istanbul, Turkey.
  • Uzun H; . Professor Doctor. Department of Medical Biochemistry, Cerrahpasa Faculty of Medicine, Istanbul University-Cerrahpasa, Istanbul, Turkey.
Rev Assoc Med Bras (1992) ; 66(8): 1128-1133, 2020 Aug.
Article em En | MEDLINE | ID: mdl-32935809
AIM: The aim of this study was to examine the roles of nitric oxide (NOx), endothelial nitric oxide synthetase (eNOS), and asymmetric dimethylarginine (ADMA), which is the major endogenous inhibitor of nitric oxide synthases (NOS), in the pathophysiology of hemorrhoidal disease. METHODS: This study included 54 patients with grades 3 and 4 internal hemorrhoidal disease and 54 patients without the disease who attended the General Surgery Clinic. NOx, eNOS, and ADMA levels were measured with the Enzyme-Linked ImmunoSorbent Assay (ELISA) method. RESULTS: The patients had higher NO and eNOS levels and lower ADMA levels than the control subjects (p<0.001). A significant highly positive correlation was found between NO and eNOS (p<0.001). Nevertheless, there was a highly negative correlation between ADMA and NO-eNOS(p<0.001, p<0.001). CONCLUSION: This preliminary study reveals that higher NOx and eNOS activities and lower ADMA levels in the rectal mucosa are observed in patients with hemorrhoidal disease than in those with normal rectal tissue. The imbalance between endothelium-derived relaxing factors, such as NO and endogenous competitive inhibitor of NOS, ADMA, may cause hemorrhoidal disease. Our study proposes that hemorrhoids display apparent vascular dilatation and present with bleeding or swelling. ADMA is an effective NOS inhibitor and may be a promising therapeutic option for hemorrhoidal disease.
Assuntos

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Hemorroidas Limite: Humans Idioma: En Revista: Rev Assoc Med Bras (1992) Ano de publicação: 2020 Tipo de documento: Article País de afiliação: Turquia País de publicação: Brasil

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Hemorroidas Limite: Humans Idioma: En Revista: Rev Assoc Med Bras (1992) Ano de publicação: 2020 Tipo de documento: Article País de afiliação: Turquia País de publicação: Brasil