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Association of the MC4R rs17782313 polymorphism with plasma ghrelin, leptin, IL6 and TNFα concentrations, food intake and eating behaviors in morbidly obese women.
Magno, Fernanda Cristina Carvalho Mattos; Guaraná, Helena Chrispim; da Fonseca, Ana Carolina Proença; Pedrosa, Aline Pereira; Zembrzuski, Verônica Marques; Cabello, Pedro Hernan; Cabello, Giselda Maria Kalil; Carneiro, João Régis Ivar; Rosado, Eliane Lopes.
Afiliação
  • Magno FCCM; Institute of Nutrition, Federal University of Rio de Janeiro, Carlos Chagas Filho Avenue, 373, CCS, Block J, 2nd Floor, University City, Fundão Island, Rio de Janeiro, RJ, 21941-590, Brazil. fernandamattos.nut@gmail.com.
  • Guaraná HC; Department of Nutrology, Federal University of Rio de Janeiro, University Hospital Clementino Fraga Filho, Professor Rodolpho Paulo Rocco Street, 255, 9th Floor, University City, Fundão Island, Rio de Janeiro, RJ, 21941-913, Brazil. fernandamattos.nut@gmail.com.
  • da Fonseca ACP; Institute of Nutrition, Federal University of Rio de Janeiro, Carlos Chagas Filho Avenue, 373, CCS, Block J, 2nd Floor, University City, Fundão Island, Rio de Janeiro, RJ, 21941-590, Brazil.
  • Pedrosa AP; Oswaldo Cruz Foundation (FIOCRUZ), Oswaldo Cruz Institute (IOC), Brazil Avenue, 4365, Leônidas Deane Building, 6th Floor, Human Genetics Laboratory, Room 615, Manguinhos, Rio de Janeiro, RJ, 21040-900, Brazil.
  • Zembrzuski VM; Oswaldo Cruz Foundation (FIOCRUZ), Oswaldo Cruz Institute (IOC), Brazil Avenue, 4365, Pavilion 108, Laboratory of Immunopharmacology, Room 44, Manguinhos, Rio de Janeiro, RJ, 21040-900, Brazil.
  • Cabello PH; Institute of Nutrition, Federal University of Rio de Janeiro, Carlos Chagas Filho Avenue, 373, CCS, Block J, 2nd Floor, University City, Fundão Island, Rio de Janeiro, RJ, 21941-590, Brazil.
  • Cabello GMK; Oswaldo Cruz Foundation (FIOCRUZ), Oswaldo Cruz Institute (IOC), Brazil Avenue, 4365, Leônidas Deane Building, 6th Floor, Human Genetics Laboratory, Room 615, Manguinhos, Rio de Janeiro, RJ, 21040-900, Brazil.
  • Carneiro JRI; Oswaldo Cruz Foundation (FIOCRUZ), Oswaldo Cruz Institute (IOC), Brazil Avenue, 4365, Leônidas Deane Building, 6th Floor, Human Genetics Laboratory, Room 615, Manguinhos, Rio de Janeiro, RJ, 21040-900, Brazil.
  • Rosado EL; Human Genetics Laboratory, Professor José de Souza Herdy Street, 1160, Jardim Vinte E Cinco de Agosto, Duque de Caxias, RJ, 25071-202, Brazil.
Eat Weight Disord ; 26(4): 1079-1087, 2021 May.
Article em En | MEDLINE | ID: mdl-32918257
PURPOSE: The rs17782313 variant of the MC4R gene plays an important role in the obesity phenotype. Studies that evaluate environmental factors and genetic variants associated with obesity may represent a great advance in understanding the development of this disease. This work seeks to assess the association of the polymorphism of MC4R rs17782313 on plasma parameters, including leptin, ghrelin, tumor necrosis factor (TNFα) and interleukin 6 (IL6), and on the eating behaviors of morbidly obese women. METHODS: 70 adult women with BMI between 40 and 60 kg/m2 were recruited. Laboratory and anthropometric data were recorded. Using a visual analog scale (VAS), the feelings of hunger and satiety were evaluated. The presence or absence of binge eating was evaluated through the Binge Eating Scale (BES) questionnaire. Habitual food intake was analyzed using 3-day dietary records. TaqMan® assays were conducted using real-time PCR to assess genotype polymorphism variants from peripheral blood DNA. RESULTS: This study found that female patients with the MC4R rs17782313 polymorphism had high levels of ghrelin and reduced levels of IL6 in the postprandial period. We observed a higher prevalence of severe binge eating in more than 50% of women with at least one risk allele. CONCLUSION: Our hypothesis is that the MC4R rs17782313 polymorphism may influence the release of ghrelin, even without being associated with feelings of hunger and satiety. More than half of women with this polymorphism exhibited severe binge eating. LEVEL OF EVIDENCE: Level III: case-control analytic study.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Obesidade Mórbida / Leptina Tipo de estudo: Prognostic_studies / Risk_factors_studies Limite: Adult / Female / Humans Idioma: En Revista: Eat Weight Disord Assunto da revista: GASTROENTEROLOGIA / METABOLISMO Ano de publicação: 2021 Tipo de documento: Article País de afiliação: Brasil País de publicação: Alemanha
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Obesidade Mórbida / Leptina Tipo de estudo: Prognostic_studies / Risk_factors_studies Limite: Adult / Female / Humans Idioma: En Revista: Eat Weight Disord Assunto da revista: GASTROENTEROLOGIA / METABOLISMO Ano de publicação: 2021 Tipo de documento: Article País de afiliação: Brasil País de publicação: Alemanha