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Treatment of Acute Toxoplasmosis in Pregnancy: Influence in the Mother-to-Child Transmission.
Bartholo, Bárbara Beatriz Garcia Raskovisch; Monteiro, Denise Leite Maia; Rodrigues, Nádia Cristina Pinheiro; Trajano, Alexandre José Baptista; de Jesus, Nilson Ramires; Cardoso, Fernanda Freitas Oliveira; de Souza, Flavio Monteiro; Werner, Heron; Araujo Júnior, Edward.
Afiliação
  • Bartholo BBGR; Department of Obstetrics, State University of Rio de Janeiro, Rio de Janeiro, Brazil.
  • Monteiro DLM; Department of Obstetrics, State University of Rio de Janeiro, Rio de Janeiro, Brazil; Department of Gynecology and Obstetrics, Serra dos Órgãos University Center, Teresópolis, Brazil.
  • Rodrigues NCP; Department of Epidemiology, State University of Rio de Janeiro, Rio de Janeiro, Brazil; Department of Epidemiology, National School of Public Health (Fiocruz), Rio de Janeiro, Brazil.
  • Trajano AJB; Department of Obstetrics, State University of Rio de Janeiro, Rio de Janeiro, Brazil; Department of Gynecology and Obstetrics, Unigranrio University, Rio de Janeiro, Brazil.
  • de Jesus NR; Department of Obstetrics, State University of Rio de Janeiro, Rio de Janeiro, Brazil; Department of Gynecology and Obstetrics, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil.
  • Cardoso FFO; Department of Obstetrics, State University of Rio de Janeiro, Rio de Janeiro, Brazil; Department of Gynecology and Obstetrics, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil.
  • de Souza FM; Department of Obstetrics, State University of Rio de Janeiro, Rio de Janeiro, Brazil.
  • Werner H; Department of Radiology, Clínica de Diagnóstico por Imagem, Rio de Janeiro, Brazil.
  • Araujo Júnior E; Department of Obstetrics, Paulista School of Medicine-Federal University of São Paulo, São Paulo, Brazil; Municipal University of São Caetano do Sul, Campus Bela Vista, São Paulo, Brazil. Electronic address: araujojred@terra.com.br.
J Obstet Gynaecol Can ; 42(12): 1505-1510, 2020 Dec.
Article em En | MEDLINE | ID: mdl-32912728
OBJECTIVE: To evaluate the association between treatment and mother-to-child transmission of acute Toxoplasma gondii infection in pregnancy. METHODS: This was a concurrent cohort study of 26 pregnant women diagnosed with acute toxoplasmosis. Transmission of T. gondii to the fetus was characterized by detection of the parasite in the amniotic fluid by polymerase chain reaction (PCR). Congenital toxoplasmosis was diagnosed by a positive serological test for IgM, intracranial calcification, chorioretinitis, hydrocephalus, and/or microcephaly in the newborn. RESULTS: There was direct correlation between acute toxoplasmosis and low socioeconomic status and inadequate hygienic/health conditions. The MCT rate in adequately and inadequately treated patients was 17.4% and 33.3%, respectively. PCR analysis of the amniotic fluid was performed for 15 women, with 1 positive result; the pregnant woman was adequately treated, and her infant had no complications. Congenital infection occurred in 4 newborns, who had hydrocephalus, intracranial calcifications, and chorioretinitis. Cerebrospinal fluid alteration was found in 3 of the 16 infants tested. Transmission was more frequent in the third quarter of pregnancy (P = 0.04). CONCLUSION: The rate of mother-to-child transmission of T. gondii is higher in untreated pregnant women and those who acquired the infection later in pregnancy.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Complicações Infecciosas na Gravidez / Toxoplasma / Toxoplasmose / Toxoplasmose Congênita Tipo de estudo: Diagnostic_studies / Etiology_studies / Incidence_studies / Observational_studies / Risk_factors_studies Limite: Adult / Female / Humans / Infant / Newborn / Pregnancy Idioma: En Revista: J Obstet Gynaecol Can Assunto da revista: GINECOLOGIA / OBSTETRICIA Ano de publicação: 2020 Tipo de documento: Article País de afiliação: Brasil País de publicação: Holanda
Texto completo
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XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Complicações Infecciosas na Gravidez / Toxoplasma / Toxoplasmose / Toxoplasmose Congênita Tipo de estudo: Diagnostic_studies / Etiology_studies / Incidence_studies / Observational_studies / Risk_factors_studies Limite: Adult / Female / Humans / Infant / Newborn / Pregnancy Idioma: En Revista: J Obstet Gynaecol Can Assunto da revista: GINECOLOGIA / OBSTETRICIA Ano de publicação: 2020 Tipo de documento: Article País de afiliação: Brasil País de publicação: Holanda