What Is the Role of the Inflammation in the Pathogenesis of Heart Failure?

Castillo, Elena C; Vázquez-Garza, Eduardo; Yee-Trejo, David; García-Rivas, Gerardo; Torre-Amione, Guillermo

Castillo, Elena C; Vázquez-Garza, Eduardo; Yee-Trejo, David; García-Rivas, Gerardo; Torre-Amione, Guillermo.

Afiliação

Castillo EC; Tecnologico de Monterrey, Escuela de Medicina y Ciencias de la Salud, Ave. Morones Prieto 3000, 64710, Monterrey, NL, Mexico.
Vázquez-Garza E; Tecnologico de Monterrey, Escuela de Medicina y Ciencias de la Salud, Ave. Morones Prieto 3000, 64710, Monterrey, NL, Mexico.
Yee-Trejo D; Tecnologico de Monterrey, Escuela de Medicina y Ciencias de la Salud, Ave. Morones Prieto 3000, 64710, Monterrey, NL, Mexico.
García-Rivas G; Tecnologico de Monterrey, Escuela de Medicina y Ciencias de la Salud, Ave. Morones Prieto 3000, 64710, Monterrey, NL, Mexico. gdejesus@tec.mx.
Torre-Amione G; Tecnologico de Monterrey, Centro de Investigación Biomédica, Hospital Zambrano Hellion, TecSalud, 66278, San Pedro Garza García, NL, Mexico. gdejesus@tec.mx.

Curr Cardiol Rep ; 22(11): 139, 2020 09 10.

Article em En | MEDLINE | ID: mdl-32910299

RESUMO

PURPOSE OF REVIEW: In heart failure, whether it is associated with reduced or preserved ejection fraction, the immune system is activated and contributes to heart remodeling and impaired function. RECENT FINDINGS: Studies indicate that cells of the immune system not only play a role in the pathology but are also critical regulators of heart function. Knowledge about the role of the immune system driving heart failure will lead to the development of new targets to this system, particularly in those patients that, despite the apparent wellness, relapse and worsen. In this review, we will address the diverse mechanisms that trigger inflammation and their impact on heart failure progression.

Assuntos

Insuficiência Cardíaca; Insuficiência Cardíaca/etiologia; Humanos; Inflamação; Volume Sistólico

Palavras-chave

Acute inflammation; Heart failure; Inflammasome; Reduced ejection fraction and preserved ejection fraction; Systemic inflammation

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Insuficiência Cardíaca Tipo de estudo: Etiology_studies Limite: Humans Idioma: En Revista: Curr Cardiol Rep Assunto da revista: CARDIOLOGIA Ano de publicação: 2020 Tipo de documento: Article País de afiliação: México País de publicação: Estados Unidos

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