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Anticancer Effect of a Spiro-acridine Compound Involves Immunomodulatory and Anti-angiogenic Actions.
Duarte, SÂmia Sousa; Silva, Daiana Karla Frade; Lisboa, ThaÍs Mangeon Honorato; Gouveia, Rawny Galdino; Ferreira, Rafael Carlos; DE Moura, Ricardo OlÍmpio; DA Silva, Jamire Muriel; DE Almeida Lima, Éssia; Rodrigues-Mascarenhas, Sandra; DA Silva, Patricia Mirella; Farias, Davi Felipe; DA Costa Ribeiro Souza, Juliana Alves; DE Paula Medeiros, Karina Carla; GonÇalves, Juan Carlos Ramos; Sobral, Marianna Vieira.
Afiliação
  • Duarte SS; Post Graduation Program in Bioactive Natural and Synthetic Products, Federal University of Paraíba, João Pessoa, Brazil.
  • Silva DKF; Post Graduation Program in Bioactive Natural and Synthetic Products, Federal University of Paraíba, João Pessoa, Brazil.
  • Lisboa TMH; Post Graduation Program in Bioactive Natural and Synthetic Products, Federal University of Paraíba, João Pessoa, Brazil.
  • Gouveia RG; Post Graduation Program in Bioactive Natural and Synthetic Products, Federal University of Paraíba, João Pessoa, Brazil.
  • Ferreira RC; Post Graduation Program in Bioactive Natural and Synthetic Products, Federal University of Paraíba, João Pessoa, Brazil.
  • DE Moura RO; Drug Development and Synthesis Laboratory, Department of Pharmacy, State University of Paraíba, João Pessoa, Brazil.
  • DA Silva JM; Post Graduation Program in Pharmaceutical Sciences, Federal University of Pernambuco, Recife, Brazil.
  • DE Almeida Lima É; Multicenter Postgraduate Program in Physiological Sciences, Federal University of Paraíba, João Pessoa, Brazil.
  • Rodrigues-Mascarenhas S; Post Graduation Program in Bioactive Natural and Synthetic Products, Federal University of Paraíba, João Pessoa, Brazil.
  • DA Silva PM; Multicenter Postgraduate Program in Physiological Sciences, Federal University of Paraíba, João Pessoa, Brazil.
  • Farias DF; Department of Molecular Biology, Federal University of Paraíba, João Pessoa, Brazil.
  • DA Costa Ribeiro Souza JA; Laboratory of Risk Assessment for Novel Technologies, Department of Molecular Biology, Federal University of Paraiba, João Pessoa, Brazil.
  • DE Paula Medeiros KC; Laboratory of Risk Assessment for Novel Technologies, Department of Molecular Biology, Federal University of Paraiba, João Pessoa, Brazil.
  • GonÇalves JCR; Department of Morphology, Federal University of Rio Grande do Norte, Natal, Brazil.
  • Sobral MV; Department of Pharmaceutical Sciences, Federal University of Paraíba, João Pessoa, Brazil.
Anticancer Res ; 40(9): 5049-5057, 2020 Sep.
Article em En | MEDLINE | ID: mdl-32878793
BACKGROUND/AIM: Studies with acridine compounds have reported anticancer effects. Herein, we evaluated the toxicity and antitumor effect of the (E)-1'-((4-chlorobenzylidene)amino)-5'-oxo-1',5'-dihydro-10H-spiro[acridine-9,2'-pyrrole]-4'-carbonitrile (AMTAC-06), a promising anticancer spiro-acridine compound. MATERIALS AND METHODS: The toxicity of AMTAC-06 was evaluated on zebrafish and mice. Antitumor activity was assessed in Ehrlich ascites carcinoma model. Effects on angiogenesis, cytokine levels and cell cycle were also investigated. RESULTS: AMTAC-06 did not induce toxicity on zebrafish and mice (LD50 approximately 5000 mg/kg, intraperitoneally). No genotoxicity was observed on micronucleus assay. AMTAC-06 significantly reduced the total viable Ehrlich tumor cells and increased sub-G1 peak, suggesting apoptosis was triggered. Moreover, the compound significantly decreased the density of peritumoral microvessels, indicating an anti-angiogenic action, possibly dependent on the cytokine modulation (TNF-α, IL-1ß and IFN-γ). No significant toxicological effects were recorded for AMTAC-06 on tumor transplanted animals. CONCLUSION: AMTAC-06 has low toxicity and a significant antitumor activity.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Compostos de Espiro / Acridinas / Inibidores da Angiogênese / Fatores Imunológicos / Antineoplásicos Tipo de estudo: Prognostic_studies Limite: Animals / Humans Idioma: En Revista: Anticancer Res Ano de publicação: 2020 Tipo de documento: Article País de afiliação: Brasil País de publicação: Grécia
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Compostos de Espiro / Acridinas / Inibidores da Angiogênese / Fatores Imunológicos / Antineoplásicos Tipo de estudo: Prognostic_studies Limite: Animals / Humans Idioma: En Revista: Anticancer Res Ano de publicação: 2020 Tipo de documento: Article País de afiliação: Brasil País de publicação: Grécia