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High temperature stress response is not sexually dimorphic at the whole-body level and is dependent on androgens to induce sex reversal.
Castañeda-Cortés, Diana C; Zhang, Jing; Boan, Agustín F; Langlois, Valerie S; Fernandino, Juan I.
Afiliação
  • Castañeda-Cortés DC; Laboratorio de Biología del Desarrollo - Instituto Tecnológico de Chascomús, INTECH (CONICET-UNSAM), Argentina.
  • Zhang J; Department of Diagnostic Imaging, Hospital for Sick Children, Toronto, ON, Canada; Neurosciences & Mental Health, SickKids Research Institute, Toronto, ON, Canada.
  • Boan AF; Laboratorio de Biología del Desarrollo - Instituto Tecnológico de Chascomús, INTECH (CONICET-UNSAM), Argentina.
  • Langlois VS; Institut National de la Recherche Scientifique (INRS) - Centre Eau Terre Environnement, Quebec, Canada. Electronic address: valerie.langlois@inrs.ca.
  • Fernandino JI; Laboratorio de Biología del Desarrollo - Instituto Tecnológico de Chascomús, INTECH (CONICET-UNSAM), Argentina. Electronic address: fernandino@intech.gov.ar.
Gen Comp Endocrinol ; 299: 113605, 2020 12 01.
Article em En | MEDLINE | ID: mdl-32866474
The understanding of the molecular and endocrine mechanisms behind environmentally-induced sex reversal in fish is of great importance in the context of predicting the potential effects of climate change, especially increasing temperature. Here, we demonstrate the global effects of high temperature on genome-wide transcription in medaka (Oryzias latipes) during early development. Interestingly, data analysis did not show sexual dimorphic changes, demonstrating that thermal stress is not dependent on genotypic sex. Additionally, our results revealed significant changes in several pathways under high temperature, such as stress response from brain, steroid biosynthesis, epigenetic mechanisms, and thyroid hormone biosynthesis, among others. These microarray data raised the question of what the exact molecular and hormonal mechanisms of action are for female-to-male sex reversal under high temperatures in fish. Complementary gene expression analysis revealed that androgen-related genes increase in females (XX) experiencing high water temperature. To test the involvement of androgens in thermal-induced sex reversal, an androgen antagonist was used to treat XX medaka under a high-temperature setup. Data clearly demonstrated failure of female-to-male sex reversal when androgen action is inhibited, corroborating the importance of androgens in environmentally-induced sex reversal.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Diferenciação Sexual / Oryzias / Caracteres Sexuais / Resposta ao Choque Térmico / Processos de Determinação Sexual / Temperatura Alta / Androgênios Tipo de estudo: Prognostic_studies Limite: Animals Idioma: En Revista: Gen Comp Endocrinol Ano de publicação: 2020 Tipo de documento: Article País de afiliação: Argentina País de publicação: Estados Unidos
Texto completo
Adicionar na Minha BVS
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XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Diferenciação Sexual / Oryzias / Caracteres Sexuais / Resposta ao Choque Térmico / Processos de Determinação Sexual / Temperatura Alta / Androgênios Tipo de estudo: Prognostic_studies Limite: Animals Idioma: En Revista: Gen Comp Endocrinol Ano de publicação: 2020 Tipo de documento: Article País de afiliação: Argentina País de publicação: Estados Unidos