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The P2X7 Receptor: Central Hub of Brain Diseases.
Andrejew, Roberta; Oliveira-Giacomelli, Ágatha; Ribeiro, Deidiane Elisa; Glaser, Talita; Arnaud-Sampaio, Vanessa Fernandes; Lameu, Claudiana; Ulrich, Henning.
Afiliação
  • Andrejew R; Department of Biochemistry, Institute of Chemistry, University of São Paulo, São Paulo, Brazil.
  • Oliveira-Giacomelli Á; Department of Biochemistry, Institute of Chemistry, University of São Paulo, São Paulo, Brazil.
  • Ribeiro DE; Department of Biochemistry, Institute of Chemistry, University of São Paulo, São Paulo, Brazil.
  • Glaser T; Department of Biochemistry, Institute of Chemistry, University of São Paulo, São Paulo, Brazil.
  • Arnaud-Sampaio VF; Department of Biochemistry, Institute of Chemistry, University of São Paulo, São Paulo, Brazil.
  • Lameu C; Department of Biochemistry, Institute of Chemistry, University of São Paulo, São Paulo, Brazil.
  • Ulrich H; Department of Biochemistry, Institute of Chemistry, University of São Paulo, São Paulo, Brazil.
Front Mol Neurosci ; 13: 124, 2020.
Article em En | MEDLINE | ID: mdl-32848594
The P2X7 receptor is a cation channel activated by high concentrations of adenosine triphosphate (ATP). Upon long-term activation, it complexes with membrane proteins forming a wide pore that leads to cell death and increased release of ATP into the extracellular milieu. The P2X7 receptor is widely expressed in the CNS, such as frontal cortex, hippocampus, amygdala and striatum, regions involved in neurodegenerative diseases and psychiatric disorders. Despite P2X7 receptor functions in glial cells have been extensively studied, the existence and roles of this receptor in neurons are still controversially discussed. Regardless, P2X7 receptors mediate several processes observed in neuropsychiatric disorders and brain tumors, such as activation of neuroinflammatory response, stimulation of glutamate release and neuroplasticity impairment. Moreover, P2X7 receptor gene polymorphisms have been associated to depression, and isoforms of P2X7 receptors are implicated in neuropsychiatric diseases. In view of that, the P2X7 receptor has been proposed to be a potential target for therapeutic intervention in brain diseases. This review discusses the molecular mechanisms underlying P2X7 receptor-mediated signaling in neurodegenerative diseases, psychiatric disorders, and brain tumors. In addition, it highlights the recent advances in the development of P2X7 receptor antagonists that are able of penetrating the central nervous system.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Idioma: En Revista: Front Mol Neurosci Ano de publicação: 2020 Tipo de documento: Article País de afiliação: Brasil País de publicação: Suíça
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Idioma: En Revista: Front Mol Neurosci Ano de publicação: 2020 Tipo de documento: Article País de afiliação: Brasil País de publicação: Suíça