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Prenatal programming of the immune response induced by maternal periodontitis: Effects on the development of acute lung injury in rat pups.
do Valle Wuo, Alexandre; Klein, Simone; de Almeida, Patrícia; Marcos, Rodrigo Labat; de Souza Setubal Destro, Maria Fernanda; de Fátma, Daniela Teixeira; Horliana, Anna Carolina Ratto Tempestini; Lino-Dos-Santos-Franco, Adriana.
Afiliação
  • do Valle Wuo A; Post Graduate Program in Biophotonics Applied to Health Sciences, University Nove de Julho (UNINOVE), São Paulo, Brazil.
  • Klein S; Post Graduate Program in Biophotonics Applied to Health Sciences, University Nove de Julho (UNINOVE), São Paulo, Brazil.
  • de Almeida P; Post Graduate Program in Biophotonics Applied to Health Sciences, University Nove de Julho (UNINOVE), São Paulo, Brazil.
  • Marcos RL; Post Graduate Program in Biophotonics Applied to Health Sciences, University Nove de Julho (UNINOVE), São Paulo, Brazil.
  • de Souza Setubal Destro MF; Post Graduate Program in Biophotonics Applied to Health Sciences, University Nove de Julho (UNINOVE), São Paulo, Brazil.
  • de Fátma DT; Post Graduate Program in Biophotonics Applied to Health Sciences, University Nove de Julho (UNINOVE), São Paulo, Brazil.
  • Horliana ACRT; Post Graduate Program in Biophotonics Applied to Health Sciences, University Nove de Julho (UNINOVE), São Paulo, Brazil.
  • Lino-Dos-Santos-Franco A; Post Graduate Program in Biophotonics Applied to Health Sciences, University Nove de Julho (UNINOVE), São Paulo, Brazil. Electronic address: alsantosfranco@gmail.com.
Life Sci ; 260: 118309, 2020 Nov 01.
Article em En | MEDLINE | ID: mdl-32841664
AIMS: Oral cavity pathogens play an important systemic role, modulating the development of several diseases. Periodontitis is a very common oral disease associated with dental biofilm. It is characterized by gum inflammation, periodontal ligament degeneration, dental cementum and alveolar bone loss. Studies point to the association between maternal periodontitis and adverse outcomes during pregnancy. However, they did not evaluate the impact of maternal periodontitis in the offspring. Thus, our objective was to investigate the effects of maternal periodontitis in the immune system of offspring. MATERIAL AND METHODS: For this evaluation we induced acute lung injury in rat pups. Pregnant rats were submitted or not to periodontitis by ligature technique. Thirty days after the birth, offspring was submitted to acute lung inflammation by administration of lipopolysaccharide (LPS, Salmonella abortus equi, 5 mg/kg, ip). KEY FINDINGS: Our results showed that maternal periodontitis increased myeloperoxidase activity, the levels of TNF-alpha and IL-17A in the bronchoalveolar fluid, the gene expression of TNF-alpha, IL-17A, and cyclooxygenases 1 and 2. In addition, maternal periodontitis did not alter the number of leukocytes migrated into the lung, tracheal responsiveness, expression of TLR4 and NF-KB translocation. SIGNIFICANCE: This study showed prenatal programming of the immune response induced by maternal periodontitis, and reinforces the importance of oral health care during pregnancy.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Periodontite / Efeitos Tardios da Exposição Pré-Natal / Reprogramação Celular / Lesão Pulmonar Aguda Tipo de estudo: Etiology_studies Limite: Animals / Pregnancy Idioma: En Revista: Life Sci Ano de publicação: 2020 Tipo de documento: Article País de afiliação: Brasil País de publicação: Holanda
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Periodontite / Efeitos Tardios da Exposição Pré-Natal / Reprogramação Celular / Lesão Pulmonar Aguda Tipo de estudo: Etiology_studies Limite: Animals / Pregnancy Idioma: En Revista: Life Sci Ano de publicação: 2020 Tipo de documento: Article País de afiliação: Brasil País de publicação: Holanda