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Associations of Uncertainty With Psychological Health and Quality of Life in Older Adults With Advanced Cancer.
Verduzco-Aguirre, Haydee C; Babu, Dilip; Mohile, Supriya G; Bautista, Javier; Xu, Huiwen; Culakova, Eva; Canin, Beverly; Zhang, Yingzi; Wells, Megan; Epstein, Ronald M; Duberstein, Paul; McHugh, Colin; Dale, William; Conlin, Alison; Bearden, James; Berenberg, Jeffrey; Tejani, Mohamedtaki; Loh, Kah Poh.
Afiliação
  • Verduzco-Aguirre HC; Department of Hemato-Oncology, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Mexico City, Mexico.
  • Babu D; Kaiser Permanente, Portland, Oregon, USA.
  • Mohile SG; James P. Wilmot Cancer Center, University of Rochester Medical Center, Rochester, New York, USA.
  • Bautista J; James P. Wilmot Cancer Center, University of Rochester Medical Center, Rochester, New York, USA.
  • Xu H; James P. Wilmot Cancer Center, University of Rochester Medical Center, Rochester, New York, USA.
  • Culakova E; James P. Wilmot Cancer Center, University of Rochester Medical Center, Rochester, New York, USA.
  • Canin B; James P. Wilmot Cancer Center, University of Rochester Medical Center, Rochester, New York, USA.
  • Zhang Y; University of Rochester School of Nursing, Rochester, New York, USA.
  • Wells M; James P. Wilmot Cancer Center, University of Rochester Medical Center, Rochester, New York, USA.
  • Epstein RM; James P. Wilmot Cancer Center, University of Rochester Medical Center, Rochester, New York, USA; Department of Psychiatry, University of Rochester School of Medicine and Dentistry, Rochester, New York, USA; Department of Family Medicine, University of Rochester School of Medicine and Dentistry, Roch
  • Duberstein P; Department of Health Behavior, Society, and Policy, Rutgers School of Public Health, Piscataway, New Jersey, USA.
  • McHugh C; James P. Wilmot Cancer Center, University of Rochester Medical Center, Rochester, New York, USA.
  • Dale W; Department of Supportive Care Medicine, City of Hope Comprehensive Cancer Center, Duarte, California, USA.
  • Conlin A; Pacific Cancer Research Consortium National Cancer Institute Community Oncology Research Program (NCORP), Seattle, Washington, USA.
  • Bearden J; Southeast Clinical Oncology Research Consortium NCORP, Winston-Salem, North Carolina, USA.
  • Berenberg J; Hawaii Minority Underserved National Cancer Institute Community Oncology Research Program (MU-NCORP), Honolulu, Hawaii, USA.
  • Tejani M; AdventHealth, Orlando, Florida, USA.
  • Loh KP; James P. Wilmot Cancer Center, University of Rochester Medical Center, Rochester, New York, USA. Electronic address: kahpoh_loh@urmc.rochester.edu.
J Pain Symptom Manage ; 61(2): 369-376.e1, 2021 02.
Article em En | MEDLINE | ID: mdl-32822750
CONTEXT: Older adults with advanced cancer face uncertainty related to their disease and treatment. OBJECTIVES: To evaluate the associations of uncertainty with psychological health and quality of life (QoL) in older adults with advanced cancer. METHODS: Secondary cross-sectional analysis of baseline data from a national clustered geriatric assessment trial. Patients 70 years and older with advanced cancer considering a new line of chemotherapy were recruited. We measured uncertainty using the modified nine-item Mishel Uncertainty in Illness Scale. Dependent variables included anxiety (Generalized Anxiety Disorder-7), depression (Generalized Depression Scale-15), distress (distress thermometer), QoL (Functional Assessment of Cancer Therapy-General), and emotional well-being (Functional Assessment of Cancer Therapy-General subscale). We used multivariate linear regression analyses to evaluate the association of uncertainty with each dependent variable. We conducted a partial least squares analysis with a variable importance in projection (VIP) plot to assess the contribution of individual variables to the model. Variables with a VIP <0.8 were considered less influential. RESULTS: We included 527 patients (median age 76 years; range 70-96). In multivariate analyses, higher levels of uncertainty were significantly associated with greater anxiety (ß = 0.11; SE = 0.04), depression (ß = 0.09; SE = 0.02), distress (ß = 0.12; SE = 0.02), as well as lower QoL (ß = -1.08; SE = 0.11) and emotional well-being (ß = -0.29; SE = 0.03); the effect sizes were considered small. Uncertainty items related to disease and treatment were most strongly associated with psychological health and QoL scores (all VIP >0.8). CONCLUSION: Uncertainty among older patients with advanced cancer is associated with worse psychological health and QoL. Tailored uncertainty management strategies are warranted.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Qualidade de Vida / Neoplasias Tipo de estudo: Observational_studies / Prevalence_studies / Prognostic_studies / Risk_factors_studies Aspecto: Patient_preference Limite: Aged / Aged80 / Humans Idioma: En Revista: J Pain Symptom Manage Assunto da revista: NEUROLOGIA / PSICOFISIOLOGIA / TERAPEUTICA Ano de publicação: 2021 Tipo de documento: Article País de afiliação: México País de publicação: Estados Unidos
Texto completo
Adicionar na Minha BVS
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XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Qualidade de Vida / Neoplasias Tipo de estudo: Observational_studies / Prevalence_studies / Prognostic_studies / Risk_factors_studies Aspecto: Patient_preference Limite: Aged / Aged80 / Humans Idioma: En Revista: J Pain Symptom Manage Assunto da revista: NEUROLOGIA / PSICOFISIOLOGIA / TERAPEUTICA Ano de publicação: 2021 Tipo de documento: Article País de afiliação: México País de publicação: Estados Unidos