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Comparing the effects of whey and casein supplementation on nutritional status and immune parameters in patients with chronic liver disease: a randomised double-blind controlled trial.
Mizubuti, Y G G; Vieira, E L M; Silva, T A; d'Alessandro, M O; Generoso, S V; Teixeira, A L; Lima, A S; Correia, M I T D.
Afiliação
  • Mizubuti YGG; Department of Surgery, University Hospital Liver Disease Program, Universidade Federal de Minas Gerais, Belo Horizonte, Minas Gerais30130-100, Brazil.
  • Vieira ELM; Department of Nutrition, Pontifícia Universidade Católica-PUC, Barreiro Unit, Belo Horizonte, Minas Gerais30640-070, Brazil.
  • Silva TA; Department of Food Science, Pós-Graduação em Ciências de Alimentos, Faculdade de Farmácia, Universidade Federal de Minas Gerais, Belo Horizonte, Minas Gerais31270-901, Brazil.
  • d'Alessandro MO; Department of Biochemistry and Immunology, Neuroscience Program, Universidade Federal de Minas Gerais, Belo Horizonte, Minas Gerais30130-100, Brazil.
  • Generoso SV; Department of Surgery, University Hospital Liver Disease Program, Universidade Federal de Minas Gerais, Belo Horizonte, Minas Gerais30130-100, Brazil.
  • Teixeira AL; Department of Surgery, University Hospital Liver Disease Program, Universidade Federal de Minas Gerais, Belo Horizonte, Minas Gerais30130-100, Brazil.
  • Lima AS; Department of Surgery, University Hospital Liver Disease Program, Universidade Federal de Minas Gerais, Belo Horizonte, Minas Gerais30130-100, Brazil.
  • Correia MITD; Department of Food Science, Pós-Graduação em Ciências de Alimentos, Faculdade de Farmácia, Universidade Federal de Minas Gerais, Belo Horizonte, Minas Gerais31270-901, Brazil.
Br J Nutr ; 125(7): 768-779, 2021 Apr 14.
Article em En | MEDLINE | ID: mdl-32807252
Protein supplementation may be beneficial for patients with chronic liver disease (CLD). This study compared the effects of whey protein isolate (WP) and casein (CA) supplementation on nutritional status and immune parameters of CLD patients who were randomly assigned to take 20 g of WP or CA twice per d as a supplement for 15 d. Body composition, muscle functionality and plasmatic immunomarkers were assessed before and after supplementation. Patients were also classified according to the model for end-stage liver disease (MELD) into less (MELD < 15) and more (MELD ≥ 15) severe disease groups. Malnutrition, determined by the Subjective Global Assessment at baseline, was observed in 57·4 % and 54·2 % of patients in the WP and CA groups, respectively (P = 0·649). Protein intake was lower at baseline in the WP group than in the CA group (P = 0·035), with no difference after supplementation (P = 0·410). Both the WP and CA MELD < 15 groups increased protein intake after supplementation according to the intragroup analysis. No differences were observed in body composition, muscle functionality, most plasma cytokines (TNF, IL-6, IL-1ß and interferon-γ), immunomodulatory proteins (sTNFR1, sTNFR2, brain-derived neurotrophic factor and glial cell line-derived neurotrophic factor) or immunomodulatory hormones (adiponectin, insulin and leptin) after supplementation in the WP groups at the two assessed moments. WP supplementation increased the levels of interferon-γ-induced protein-10/CXCL10 (P = 0·022), eotaxin-1/CCL11 (P = 0·031) and monocyte chemoattractant protein-1/CCL2 (P = 0·018) and decreased IL-5 (P = 0·027), including among those in the MELD ≥ 15 group, for whom IL-10 was also increased (P = 0·008). Thus, WP consumption by patients with CLD impacted the immunomodulatory responses when compared with CA with no impact on nutritional status.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Tipo de estudo: Clinical_trials / Prognostic_studies Idioma: En Revista: Br J Nutr Ano de publicação: 2021 Tipo de documento: Article País de afiliação: Brasil País de publicação: Reino Unido

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Tipo de estudo: Clinical_trials / Prognostic_studies Idioma: En Revista: Br J Nutr Ano de publicação: 2021 Tipo de documento: Article País de afiliação: Brasil País de publicação: Reino Unido