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Strength exercise reduces hepatic pyruvate carboxylase and gluconeogenesis in DIO mice.
Pereira, Rodrigo Martins; Rodrigues, Kellen Cristina da Cruz; Sant'Ana, Marcella Ramos; Peruca, Guilherme Francisco; Morelli, Ana Paula; Simabuco, Fernando M; da Silva, Adelino S R; Cintra, Dennys Esper; Ropelle, Eduardo Rochete; Pauli, José Rodrigo; de Moura, Leandro Pereira.
Afiliação
  • Pereira RM; Exercise Cell Biology Lab, Faculty of Applied Sciences, State University of Campinas, Limeira, Brazil.
  • Rodrigues KCDC; Exercise Cell Biology Lab, Faculty of Applied Sciences, State University of Campinas, Limeira, Brazil.
  • Sant'Ana MR; Laboratory of Nutritional Genomics, Faculty of Applied Sciences, State University of Campinas, Limeira, Brazil.
  • Peruca GF; Exercise Cell Biology Lab, Faculty of Applied Sciences, State University of Campinas, Limeira, Brazil.
  • Morelli AP; Multidisciplinary Laboratory of Food and Health, State University of Campinas, Faculty of Applied Sciences, Limeira, Brazil.
  • Simabuco FM; Multidisciplinary Laboratory of Food and Health, State University of Campinas, Faculty of Applied Sciences, Limeira, Brazil.
  • da Silva ASR; School of Physical Education and Sport of Ribeirão Preto, University of São Paulo (USP), Ribeirão Preto, São Paulo, Brazil.
  • Cintra DE; Postgraduate Program in Rehabilitation and Functional Performance, Ribeirão Preto Medical School, USP, Ribeirão Preto, São Paulo, Brazil.
  • Ropelle ER; Laboratory of Nutritional Genomics, Faculty of Applied Sciences, State University of Campinas, Limeira, Brazil.
  • Pauli JR; Laboratory of Molecular Biology of Exercise (LaBMEx), Faculty of Applied Sciences, State University of Campinas (UNICAMP), Limeira, São Paulo, Brazil.
  • de Moura LP; Laboratory of Molecular Biology of Exercise (LaBMEx), Faculty of Applied Sciences, State University of Campinas (UNICAMP), Limeira, São Paulo, Brazil.
J Endocrinol ; 247(2): 127-138, 2020 11.
Article em En | MEDLINE | ID: mdl-32805709
Obesity is linked to a reduction in the control of hepatic glucose production, which is the primary mechanism related to fasting hyperglycemia and the development of type 2 diabetes mellitus (T2DM). The main system involved in hepatic gluconeogenesis synthesis is controlled by pyruvate carboxylase (PC), which increases in obesity conditions. Recently, we showed that short-term strength training is an important tool against obesity-induced hyperglycemia. As aerobic exercise can reduce the hepatic PC content of obese animals, we hypothesized that strength exercise can also decrease this gluconeogenic enzyme. Therefore, this study investigated whether the metabolic benefits promoted by short-term strength training are related to changes in hepatic PC content. Swiss mice were divided into three groups: lean control (Ctl), obese sedentary (ObS), and obese short-term strength training (STST). The STST protocol was performed through one session/day for 15 days. The obese exercised animals had reduced hyperglycemia and insulin resistance. These results were related to better control of hepatic glucose production and hepatic insulin sensitivity. Our bioinformatics analysis showed that hepatic PC mRNA levels have positive correlations with glucose levels and adiposity, and negative correlations with locomotor activity and muscle mass. We also found that hepatic mRNA levels are related to lipogenic markers in the liver. Finally, we observed that the obese animals had an increased hepatic PC level; however, STST was efficient in reducing its amount. In conclusion, we provide insights into new biomolecular mechanisms by showing how STST is an efficient tool against obesity-related hyperglycemia and T2DM, even without body weight changes.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Adiposidade / Glucose / Fígado / Obesidade Limite: Animals Idioma: En Revista: J Endocrinol Ano de publicação: 2020 Tipo de documento: Article País de afiliação: Brasil País de publicação: Reino Unido
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Adiposidade / Glucose / Fígado / Obesidade Limite: Animals Idioma: En Revista: J Endocrinol Ano de publicação: 2020 Tipo de documento: Article País de afiliação: Brasil País de publicação: Reino Unido