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Conjugation of superparamagnetic iron oxide nanoparticles and curcumin photosensitizer to assist in photodynamic therapy.
de Santana, Willian Max O S; Caetano, Bruno L; de Annunzio, Sarah Raquel; Pulcinelli, Sandra H; Ménager, Christine; Fontana, Carla Raquel; Santilli, Celso V.
Afiliação
  • de Santana WMOS; Institute of Chemistry, São Paulo State University (UNESP), Araraquara, São Paulo, 14800-900, Brazil.
  • Caetano BL; School of Pharmaceutical Sciences, São Paulo State University (UNESP), Araraquara, São Paulo, 14800-903, Brazil; Soft Matter Sciences and Engineering, ESPCI Paris, PSL University, Sorbonne Université, CNRS, F-75005 Paris, France; Physico-chimie des Electrolytes et Nanosystèmes Interfaciaux, PHENIX,
  • de Annunzio SR; School of Pharmaceutical Sciences, São Paulo State University (UNESP), Araraquara, São Paulo, 14800-903, Brazil.
  • Pulcinelli SH; Institute of Chemistry, São Paulo State University (UNESP), Araraquara, São Paulo, 14800-900, Brazil.
  • Ménager C; Physico-chimie des Electrolytes et Nanosystèmes Interfaciaux, PHENIX, Sorbonne Université, CNRS, F-75005 Paris, France.
  • Fontana CR; School of Pharmaceutical Sciences, São Paulo State University (UNESP), Araraquara, São Paulo, 14800-903, Brazil.
  • Santilli CV; Institute of Chemistry, São Paulo State University (UNESP), Araraquara, São Paulo, 14800-900, Brazil. Electronic address: cv.santilli@unesp.br.
Colloids Surf B Biointerfaces ; 196: 111297, 2020 Dec.
Article em En | MEDLINE | ID: mdl-32791474
In this work, we describe the synthesis and characterization of the SPIONP-CUR conjugate between curcumin (CUR) and superparamagnetic iron oxide nanoparticles (SPIONPs), in addition to its application in photodynamic therapy (PDT) using a protocol free of organic solvents as a dispersant. The SPIONP-CUR conjugate was characterized by X-ray diffraction, transmission electron microscopy, zeta potential measurements, Fourier transform infrared spectroscopy, thermogravimetry, magnetometry and magnetic hyperthermia assays. The SPIONP-CUR conjugation occurred by bonding between the keto-enol moiety of CUR and the iron atoms present on the surfaces of the SPIONPs. The conjugate showed heating power under an alternating magnetic field (AMF) and photodynamic action when irradiated with blue LED light. In experiments using PDT against Staphylococcus aureus in the planktonic phase, it was demonstrated that with application of blue light at 3.12 J cm-2, the conjugate (dispersed in water) caused a total reduction of the bacterial load. In the absence of light, the reduction was insignificant, even after 24 h of contact with the bacteria.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Fotoquimioterapia / Curcumina / Nanopartículas Tipo de estudo: Guideline Idioma: En Revista: Colloids Surf B Biointerfaces Assunto da revista: QUIMICA Ano de publicação: 2020 Tipo de documento: Article País de afiliação: Brasil País de publicação: Holanda
Texto completo
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Fotoquimioterapia / Curcumina / Nanopartículas Tipo de estudo: Guideline Idioma: En Revista: Colloids Surf B Biointerfaces Assunto da revista: QUIMICA Ano de publicação: 2020 Tipo de documento: Article País de afiliação: Brasil País de publicação: Holanda