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Neuroinflammation at single cell level: What is new?
Brandão, W N; De Oliveira, M G; Andreoni, R T; Nakaya, H; Farias, A S; Peron, J P S.
Afiliação
  • Brandão WN; Neuroimmune Interactions Laboratory, Institute of Biomedical Sciences, Department of Immunology, University of Sao Paulo, São Paulo, Brazil.
  • De Oliveira MG; Neuroimmune Interactions Laboratory, Institute of Biomedical Sciences, Department of Immunology, University of Sao Paulo, São Paulo, Brazil.
  • Andreoni RT; Neuroimmune Interactions Laboratory, Institute of Biomedical Sciences, Department of Immunology, University of Sao Paulo, São Paulo, Brazil.
  • Nakaya H; Department of Clinical and Toxicological Analyses, School of Pharmaceutical Sciences, University of São Paulo (USP), São Paulo, Brazil.
  • Farias AS; Autoimmune Research Laboratory, Department of Genetics, Microbiology and Immunology - Institute of Biology, University of Campinas, Campinas, Brazil.
  • Peron JPS; Experimental Medicine Research Cluster (EMRC), Division of Immune-Mediated Diseases.
J Leukoc Biol ; 108(4): 1129-1137, 2020 10.
Article em En | MEDLINE | ID: mdl-32779279
Multiple sclerosis is a chronic and demyelinating disease of the central nervous system (CNS), most prevalent in women, and with an important social and economic cost worldwide. It is triggered by self-reacting lymphocytes that infiltrate the CNS and initiate neuroinflammation. Further, axonal loss and neuronal death takes place, leading to neurodegeneration and brain atrophy. The murine model for studying MS, experimental autoimmune encephalomyelitis (EAE), consists in immunizing mice with myelin-derived epitopes. APCs activate encephalitogenic T CD4 and CD8 lymphocytes that migrate mainly to the spinal cord resulting in neuroinflammation. Most of the knowledge on the pathophysiology and treatment of MS was obtained from EAE experiments, as Th17 cells, anti-alpha4 blocking Abs and the role of microbiota. Conversely, recent technology breakthroughs, such as CyTOF and single-cell RNA-seq, promise to revolutionize our understanding on the mechanisms involved both in MS and EAE. In fact, the importance of specific cellular populations and key molecules in MS/EAE is a constant matter of debate. It is well accepted that both Th1 and Th17 T CD4 lymphocytes play a relevant role in disease initiation after re-activation in situ. What is still under constant investigation, however, is the plasticity of the lymphocyte population, and the individual contribution of both resident and inflammatory cells for the progression or recovery of the disease. Thus, in this review, new findings obtained after single-cell analysis of blood and central nervous system infiltrating cells from MS/EAE and how they have contributed to a better knowledge on the cellular and molecular mechanisms of neuroinflammation are discussed.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Células Th1 / Linfócitos T CD8-Positivos / Encefalomielite Autoimune Experimental / Células Th17 / Análise de Célula Única / Esclerose Múltipla Tipo de estudo: Prognostic_studies Limite: Animals / Humans Idioma: En Revista: J Leukoc Biol Ano de publicação: 2020 Tipo de documento: Article País de afiliação: Brasil País de publicação: Reino Unido
Texto completo
Adicionar na Minha BVS
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Células Th1 / Linfócitos T CD8-Positivos / Encefalomielite Autoimune Experimental / Células Th17 / Análise de Célula Única / Esclerose Múltipla Tipo de estudo: Prognostic_studies Limite: Animals / Humans Idioma: En Revista: J Leukoc Biol Ano de publicação: 2020 Tipo de documento: Article País de afiliação: Brasil País de publicação: Reino Unido