Intracerebral transfection of anti-rabies virus antibodies is an effective therapy for rabies.
J Neurovirol
; 26(5): 764-768, 2020 10.
Article
em En
| MEDLINE
| ID: mdl-32725420
Rabies is a neurological disease with 100% lethality. Some of the rare human patients who survived after multiple drug treatment had severe sequelae. The present study showed that after 48 h of RABV inoculation, mice injected intracerebrally with anti-RABV F (ab')2 plus Bioporter® showed 70% survival compared to the control group, suggesting that transfection of anti-RABV antibodies to the brain may prevent or delay the spread of RABV at an early stage of infection. This result may provide important protocol results in intracellular antibody delivery to prevent the fatal outcome of the disease.
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Raiva
/
Vírus da Raiva
/
Fragmentos Fab das Imunoglobulinas
/
Vacina Antirrábica
/
Vacinação
/
Sistemas de Liberação de Medicamentos
/
Anticorpos Antivirais
Tipo de estudo:
Guideline
Limite:
Animals
/
Female
/
Humans
Idioma:
En
Revista:
J Neurovirol
Assunto da revista:
NEUROLOGIA
/
VIROLOGIA
Ano de publicação:
2020
Tipo de documento:
Article
País de afiliação:
Brasil
País de publicação:
Estados Unidos