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Neurocysticercosis and pharmacoresistant epilepsy: possible role of calcified lesions in epileptogenesis.
Schmid, Marcelo Freitas; Perosa, Sandra Regina; Reyes-Garcia, Selvin Zacarias; Odreman, Marlene Mayzs; Zetehaku, Ana Carolina; Figueiredo, Nathalia Stela Visona; Duarte, Jeana Torres Corso; Guaranha, Mirian Salvadori Bittar; Mazacoratti, Maria da Graça Naffah; Jr, Henrique Carrete; Centeno, Ricardo Silva; Yacubian, Elza Márcia Targas.
Afiliação
  • Schmid MF; Department of Neurology and Neurosurgery, Universidade Federal de São Paulo (UNIFESP), São Paulo/SP, Brazil.
  • Perosa SR; Department of Neurology and Neurosurgery, Universidade Federal de São Paulo (UNIFESP), São Paulo/SP, Brazil.
  • Reyes-Garcia SZ; Department of Morphological Sciences, Medical Sciences Faculty, National Autonomous University of Honduras, Honduras.
  • Odreman MM; Department of Neurology and Neurosurgery, Universidade Federal de São Paulo (UNIFESP), São Paulo/SP, Brazil.
  • Zetehaku AC; Department of Neurology and Neurosurgery, Universidade Federal de São Paulo (UNIFESP), São Paulo/SP, Brazil.
  • Figueiredo NSV; Department of Neurology and Neurosurgery, Universidade Federal de São Paulo (UNIFESP), São Paulo/SP, Brazil.
  • Duarte JTC; Department of Neurology and Neurosurgery, Universidade Federal de São Paulo (UNIFESP), São Paulo/SP, Brazil.
  • Guaranha MSB; Department of Neurology and Neurosurgery, Universidade Federal de São Paulo (UNIFESP), São Paulo/SP, Brazil.
  • Mazacoratti MDGN; Department of Neurology and Neurosurgery, Universidade Federal de São Paulo (UNIFESP), São Paulo/SP, Brazil.
  • Jr HC; Department of Radiology, Universidade Federal de São Paulo (UNIFESP), São Paulo/SP, Brazil.
  • Centeno RS; Department of Neurology and Neurosurgery, Universidade Federal de São Paulo (UNIFESP), São Paulo/SP, Brazil.
  • Yacubian EMT; Department of Neurology and Neurosurgery, Universidade Federal de São Paulo (UNIFESP), São Paulo/SP, Brazil.
Epileptic Disord ; 22(4): 506-510, 2020 Aug 01.
Article em En | MEDLINE | ID: mdl-32723704
Neurocysticercosis is a neglected and usually poverty-related disease of high public importance. The mechanisms by which the calcified lesions cause epilepsy are not known, but have been attributed to residual perilesional gliosis or an inflammatory process. This case shows that an inflammatory response to a calcified granuloma may be associated with the development of epilepsy. The increase in glutamate and kinin B1 (pro-epileptogenic) receptors added by reduced expression of kinin B2 (anti-epileptogenic) receptors may explain the chronic epileptogenesis associated with the lesion, corroborating the hypothesis of inflammatory mechanisms involved in the pathophysiology of epilepsy in these patients.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Neurocisticercose / Epilepsia Resistente a Medicamentos Tipo de estudo: Diagnostic_studies / Etiology_studies Limite: Child / Female / Humans Idioma: En Revista: Epileptic Disord Assunto da revista: CEREBRO / NEUROLOGIA Ano de publicação: 2020 Tipo de documento: Article País de afiliação: Brasil País de publicação: Estados Unidos
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Neurocisticercose / Epilepsia Resistente a Medicamentos Tipo de estudo: Diagnostic_studies / Etiology_studies Limite: Child / Female / Humans Idioma: En Revista: Epileptic Disord Assunto da revista: CEREBRO / NEUROLOGIA Ano de publicação: 2020 Tipo de documento: Article País de afiliação: Brasil País de publicação: Estados Unidos