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Resistance training promotes reduction in Visceral Adiposity without improvements in Cardiomyocyte Contractility and Calcium handling in Obese Rats.
Melo, Alexandre Barroso; Damiani, Andressa Prata Leite; Coelho, Priscila Murucci; de Assis, Arícia Leone Evangelista Monteiro; Nogueira, Breno Valentim; Guimarães Ferreira, Lucas; Leite, Richard Diego; Ribeiro Júnior, Rogério Faustino; Lima-Leopoldo, Ana Paula; Leopoldo, André Soares.
Afiliação
  • Melo AB; Centre for Physical Education and Sports, Department of Sports, Federal University of Espírito Santo, Vitória, Espírito Santo, Brazil.
  • Damiani APL; Centre for Health Sciences, Department of Nutrition, Federal University of Espírito Santo, Vitória, Espírito Santo, Brazil.
  • Coelho PM; Centre for Health Sciences, Department of Nutrition, Federal University of Espírito Santo, Vitória, Espírito Santo, Brazil.
  • de Assis ALEM; Center of Health Sciences, Department of Morphology, Federal University of Espírito Santo, Vitória, Espírito Santo, Brazil.
  • Nogueira BV; Center of Health Sciences, Department of Morphology, Federal University of Espírito Santo, Vitória, Espírito Santo, Brazil.
  • Guimarães Ferreira L; Centre for Physical Education and Sports, Department of Sports, Federal University of Espírito Santo, Vitória, Espírito Santo, Brazil.
  • Leite RD; Centre for Physical Education and Sports, Department of Sports, Federal University of Espírito Santo, Vitória, Espírito Santo, Brazil.
  • Ribeiro Júnior RF; Center of Health Sciences, Department of Physiological Sciences, Federal University of Espírito Santo, Vitória, Espírito Santo, Brazil.
  • Lima-Leopoldo AP; Centre for Physical Education and Sports, Department of Sports, Federal University of Espírito Santo, Vitória, Espírito Santo, Brazil.
  • Leopoldo AS; Centre for Physical Education and Sports, Department of Sports, Federal University of Espírito Santo, Vitória, Espírito Santo, Brazil.
Int J Med Sci ; 17(12): 1819-1832, 2020.
Article em En | MEDLINE | ID: mdl-32714085
Resistance training (RT) improves the cardiomyocyte calcium (Ca2+) cycling during excitation-contraction coupling. However, the role of RT in cardiomyocyte contractile function associated with Ca2+ handling in obesity is unclear. Wistar rats were distributed into four groups: control, sedentary obese, control plus RT, and obesity plus RT. The 10-wk RT protocol was used (4-5 vertical ladder climbs, 60-second interval, 3× a week, 50-100% of maximum load). Metabolic, hormonal, cardiovascular and biochemical parameters were determined. Reduced leptin levels, epididymal, retroperitoneal and visceral fat pads, lower body fat, and adiposity index were observed in RT. Obesity promoted elevation of collagen, but RT did not promote modifications of LV collagen in ObRT. RT induced elevation in maximum rates of contraction and relaxation, and reduction of time to 50% relaxation. ObRT group did not present improvement in the cardiomyocyte contractile function in comparison to Ob group. Reduced cardiac PLB serine16 phosphorylation (pPLB Ser16) and pPLB Ser16/PLB ratio with no alterations in sarcoplasmic reticulum Ca2+ ATPase (SERCA2a) and phospholamban (PLB) expression were observed in Ob groups. Resistance training improved body composition reduced fat pads and plasma leptin levels but did not promote positive alterations in cardiomyocyte contractile function, Ca2+ handling and phospholamban phosphorylation.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Gordura Intra-Abdominal / Treinamento Resistido / Contração Miocárdica / Obesidade Limite: Animals / Humans Idioma: En Revista: Int J Med Sci Assunto da revista: MEDICINA Ano de publicação: 2020 Tipo de documento: Article País de afiliação: Brasil País de publicação: Austrália
Texto completo
Adicionar na Minha BVS
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XML
PubMed Links
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Gordura Intra-Abdominal / Treinamento Resistido / Contração Miocárdica / Obesidade Limite: Animals / Humans Idioma: En Revista: Int J Med Sci Assunto da revista: MEDICINA Ano de publicação: 2020 Tipo de documento: Article País de afiliação: Brasil País de publicação: Austrália