Getting intimate: Lysosomes and ER rendezvous to control autophagy.

Pihán, Philippe; Hetz, Claudio

Pihán, Philippe; Hetz, Claudio.

Afiliação

Pihán P; Biomedical Neuroscience Institute, Faculty of Medicine, University of Chile, Santiago, Chile; Center for Geroscience, Brain Health and Metabolism, Santiago, Chile; Program of Cellular and Molecular Biology, Institute of Biomedical Sciences, University of Chile, Santiago, Chile.
Hetz C; Biomedical Neuroscience Institute, Faculty of Medicine, University of Chile, Santiago, Chile; Center for Geroscience, Brain Health and Metabolism, Santiago, Chile; Program of Cellular and Molecular Biology, Institute of Biomedical Sciences, University of Chile, Santiago, Chile; Buck Institute for Research on Aging, Novato, CA, 94945, USA. Electronic address: chetz@med.uchile.cl.

Cell Calcium ; 91: 102249, 2020 11.

Article em En | MEDLINE | ID: mdl-32711245

RESUMO

The endoplasmic reticulum (ER) is the source of lysosomal calcium. The finding that the protein TMBIM6 -a putative ER calcium channel and cell death regulator -promotes calcium transfer from the ER to lysosomes to induce autophagy uncovers a missing piece in the puzzle of inter-organelle communication.

Assuntos

Autofagia; Retículo Endoplasmático/metabolismo; Lisossomos/metabolismo; Animais; Cálcio/metabolismo; Humanos; Concentração de Íons de Hidrogênio; Modelos Biológicos

Palavras-chave

Autophagy; Calcium; ER stress; Lysosome; Protein misfolding; UPR

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Autofagia / Retículo Endoplasmático / Lisossomos Tipo de estudo: Prognostic_studies Limite: Animals / Humans Idioma: En Revista: Cell Calcium Ano de publicação: 2020 Tipo de documento: Article País de afiliação: Chile País de publicação: Holanda

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