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Anti-Aging Effect of Metformin: A Molecular and Therapeutical Perspective.
Torres, Wheeler; Nava, Manuel; Galbán, Nestor; Gómez, Yosselin; Morillo, Valery; Rojas, Milagros; Cano, Clímaco; Chacín, Maricarmen; D Marco, Luis; Herazo, Yaneth; Velasco, Manuel; Bermúdez, Valmore; Rojas-Quintero, Joselyn.
Afiliação
  • Torres W; Endocrine and Metabolic Diseases Research Center, School of Medicine, University of Zulia, Maracaibo, Venezuela
  • Nava M; Endocrine and Metabolic Diseases Research Center, School of Medicine, University of Zulia, Maracaibo, Venezuela
  • Galbán N; Endocrine and Metabolic Diseases Research Center, School of Medicine, University of Zulia, Maracaibo, Venezuela
  • Gómez Y; Endocrine and Metabolic Diseases Research Center, School of Medicine, University of Zulia, Maracaibo, Venezuela
  • Morillo V; Endocrine and Metabolic Diseases Research Center, School of Medicine, University of Zulia, Maracaibo, Venezuela
  • Rojas M; Endocrine and Metabolic Diseases Research Center, School of Medicine, University of Zulia, Maracaibo, Venezuela
  • Cano C; Endocrine and Metabolic Diseases Research Center, School of Medicine, University of Zulia, Maracaibo, Venezuela
  • Chacín M; Universidad Simón Bolívar, Facultad de Ciencias de la Salud, Barranquilla, Colombia
  • D Marco L; Hospital Clínico Universitario, INCLIVA, Nephrology Department, Valencia, España
  • Herazo Y; Universidad Simón Bolívar, Facultad de Ciencias de la Salud, Barranquilla, Colombia
  • Velasco M; Clinical Pharmacologic Unit, Vargas School of Medicine, Universidad Central de Venezuela, Caracas, Venezuela
  • Bermúdez V; Universidad Simón Bolívar, Facultad de Ciencias de la Salud, Barranquilla, Colombia
  • Rojas-Quintero J; Pulmonary and Critical Care Medicine Department, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA
Curr Pharm Des ; 26(35): 4496-4508, 2020.
Article em En | MEDLINE | ID: mdl-32674728
Aging is a time-dependent inevitable process, in which cellular homeostasis is affected, which has an impact on tissue function. This represents a risk factor for the development of numerous non-transmissible diseases. In consequence, the scientific community continues to search for therapeutic measures capable of improving quality of life and delaying cellular aging. At the center of this research is metformin, a widely used drug in Type 2 Diabetes Mellitus treatment that has a reduced adverse effects profile. Furthermore, there is evidence that this drug has beneficial health effects that go beyond its anti-hyperglycemic properties. Among these effects, its geronto-protection capability stands out. There is growing evidence that points out to an increased life expectancy as well as the quality of life in model organisms treated with metformin. Therefore, there is an abundance of research centered on elucidating the mechanism through which metformin has its anti-aging effects. Among these, the AMPK, mTORC1, SIRT1, FOXO, NF.kB, and DICER1 pathways can be mentioned. Furthermore, studies have highlighted the possibility of a role for the gut microbiome in these processes. The next step is the design of clinical essays that have as a goal evaluating the efficacy and safety of metformin as an anti-aging drug in humans to create a paradigm in the medical horizon. The question being if metformin is, in fact, the new antiaging therapy in humans?
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Diabetes Mellitus Tipo 2 / Metformina Tipo de estudo: Prognostic_studies / Risk_factors_studies Aspecto: Patient_preference Limite: Humans Idioma: En Revista: Curr Pharm Des Assunto da revista: FARMACIA Ano de publicação: 2020 Tipo de documento: Article País de afiliação: Venezuela País de publicação: Emirados Árabes Unidos
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Diabetes Mellitus Tipo 2 / Metformina Tipo de estudo: Prognostic_studies / Risk_factors_studies Aspecto: Patient_preference Limite: Humans Idioma: En Revista: Curr Pharm Des Assunto da revista: FARMACIA Ano de publicação: 2020 Tipo de documento: Article País de afiliação: Venezuela País de publicação: Emirados Árabes Unidos