Your browser doesn't support javascript.
loading
Bioactive Polyphenols from Southern Chile Seaweed as Inhibitors of Enzymes for Starch Digestion.
Pacheco, Luz Verónica; Parada, Javier; Pérez-Correa, José Ricardo; Mariotti-Celis, María Salomé; Erpel, Fernanda; Zambrano, Angara; Palacios, Mauricio.
Afiliação
  • Pacheco LV; Graduate School, Faculty of Agricultural Sciences, Universidad Austral de Chile, Valdivia 5090000, Chile.
  • Parada J; Institute of Food Science and Technology, Faculty of Agricultural Sciences, Universidad Austral de Chile, Valdivia 5090000, Chile.
  • Pérez-Correa JR; Department of Chemical and Bioprocess Engineering, Pontificia Universidad Católica de Chile, Macul, Santiago 7810000, Chile.
  • Mariotti-Celis MS; Programa Institucional de Fomento a la Investigación, Desarrollo e Innovación, Universidad Tecnológica Metropolitana, Santiago 8940577, Chile.
  • Erpel F; Department of Chemical and Bioprocess Engineering, Pontificia Universidad Católica de Chile, Macul, Santiago 7810000, Chile.
  • Zambrano A; Instituto de Bioquímica y Microbiología, Facultad de Ciencias, Universidad Austral de Chile, Valdivia 5090000, Chile.
  • Palacios M; Centro FONDAP de Investigación Dinámica de Ecosistemas Marinos de Altas Latitudes (IDEAL), Valdivia 5090000, Chile.
Mar Drugs ; 18(7)2020 Jul 08.
Article em En | MEDLINE | ID: mdl-32650394
The increment of non-communicable chronic diseases is a constant concern worldwide, with type-2 diabetes mellitus being one of the most common illnesses. A mechanism to avoid diabetes-related hyperglycemia is to reduce food digestion/absorption by using anti-enzymatic (functional) ingredients. This research explored the potential of six common Chilean seaweeds to obtain anti-hyperglycemic polyphenol extracts, based on their capacity to inhibit key enzymes related with starch digestion. Ethanol/water hot pressurized liquid extraction (HPLE), which is an environmentally friendly method, was studied and compared to conventional extraction with acetone. Total polyphenols (TP), antioxidant activity, cytotoxicity and inhibition capacity on α-glucosidase and α-amylase were analyzed. Results showed that the Durvillaea antarctica (cochayuyo) acetone extract had the highest TP content (6.7 ± 0.7 mg gallic acid equivalents (GAE)/g dry seaweed), while its HPLE ethanol/water extract showed the highest antioxidant activity (680.1 ± 11.6 µmol E Trolox/g dry seaweed). No extract affected cell viability significantly. Only cochayuyo produced extracts having relevant anti-enzymatic capacity on both studied enzymes, showing a much stronger inhibition to α-glucosidase (even almost 100% at 1000 µg/mL) than to α-amylase. In conclusion, from the Chilean seaweeds considered in this study, cochayuyo is the most suitable for developing functional ingredients to moderate postprandial glycemic response (starchy foods), since it showed a clear enzymatic inhibition capacity and selectivity.
Assuntos
Palavras-chave
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Alga Marinha / Amido / Polifenóis / Inibidores de Glicosídeo Hidrolases Limite: Humans País/Região como assunto: America do sul / Chile Idioma: En Revista: Mar Drugs Assunto da revista: BIOLOGIA / FARMACOLOGIA Ano de publicação: 2020 Tipo de documento: Article País de afiliação: Chile País de publicação: Suíça
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Alga Marinha / Amido / Polifenóis / Inibidores de Glicosídeo Hidrolases Limite: Humans País/Região como assunto: America do sul / Chile Idioma: En Revista: Mar Drugs Assunto da revista: BIOLOGIA / FARMACOLOGIA Ano de publicação: 2020 Tipo de documento: Article País de afiliação: Chile País de publicação: Suíça