Your browser doesn't support javascript.
loading
Biological Evaluation of Selected 1,2,3-triazole Derivatives as Antibacterial and Antibiofilm Agents.
André, Lialyz Soares Pereira; Pereira, Renata Freire Alves; Pinheiro, Felipe Ramos; Pascoal, Aislan Cristina Rheder Fagundes; Ferreira, Vitor Francisco; de Carvalho da Silva, Fernando; Gonzaga, Daniel Tadeu Gomes; Costa, Dora Cristina Silva; Ribeiro, Tainara; Sachs, Daniela; Aguiar-Alves, Fábio.
Afiliação
  • André LSP; Universidade Fluminense Federal, Molecular Epidemiology and Biotechnology Laboratory (LEMB), Rodolpho Albino University Laboratory (LURA), Niterói-RJ, Brazil
  • Pereira RFA; Universidade Federal Fluminense, Graduate Program in Pathology and Graduate Program in Applied Microbiology and Parasitology, Niterói-RJ, Brazil
  • Pinheiro FR; Universidade Fluminense Federal, Molecular Epidemiology and Biotechnology Laboratory (LEMB), Rodolpho Albino University Laboratory (LURA), Niterói-RJ, Brazil
  • Pascoal ACRF; Universidade Federal Fluminense, Graduate Program in Biotechnology, Niterói-RJ, Brazil
  • Ferreira VF; Universidade Fluminense Federal, Molecular Epidemiology and Biotechnology Laboratory (LEMB), Rodolpho Albino University Laboratory (LURA), Niterói-RJ, Brazil
  • de Carvalho da Silva F; Universidade Federal Fluminense, Graduate Program in Pathology and Graduate Program in Applied Microbiology and Parasitology, Niterói-RJ, Brazil
  • Gonzaga DTG; Universidade Federal Fluminense, Department of Basic Sciences, Nova Friburgo Health Institute, Nova Friburgo-RJ, Brazil
  • Costa DCS; Universidade Federal Fluminense, Department of Pharmaceutical Technology, Pharmacy School, Niterói-RJ, Brazil
  • Ribeiro T; Universidade Federal Fluminense, Instituto de Química, Departamento de Química Orgânica, Niterói-RJ, Brazil
  • Sachs D; Universidade Estadual da Zona Oeste, Rio de Janeiro-RJ, Brazil
  • Aguiar-Alves F; Universidade Federal Fluminense, Instituto de Química, Departamento de Química Orgânica, Niterói-RJ, Brazil
Curr Top Med Chem ; 20(24): 2186-2191, 2020.
Article em En | MEDLINE | ID: mdl-32648843
BACKGROUND: Resistance to antimicrobial agents is a major public health problem, being Staphylococcus aureus prevalent in infections in hospital and community environments and, admittedly, related to biofilm formation in biotic and abiotic surfaces. Biofilms form a complex and structured community of microorganisms surrounded by an extracellular matrix adhering to each other and to a surface that gives them even more protection from and resistance against the action of antimicrobial agents, as well as against host defenses. METHODS: Aiming to control and solve these problems, our study sought to evaluate the action of 1,2,3- triazoles against a Staphylococcus aureus isolate in planktonic and in the biofilm form, evaluating the activity of this triazole through Minimum Inhibitory Concentration (MIC) and Minimum Bactericidal Concentration (MBC) tests. We have also performed cytotoxic evaluation and Scanning Electron Microscopy (SEM) of the biofilms under the treatment of the compound. The 1,2,3-triazole DAN 49 showed bacteriostatic and bactericidal activity (MIC and MBC 128 µg/mL). In addition, its presence interfered with the biofilm formation stage (1/2 MIC, p <0.000001) and demonstrated an effect on young preformed biofilm (2 MICs, p <0.05). RESULTS: Scanning Electron Microscopy images showed a reduction in the cell population and the appearance of deformations on the surface of some bacteria in the biofilm under treatment with the compound. CONCLUSION: Therefore, it was possible to conclude the promising anti-biofilm potential of 1,2,3-triazole, demonstrating the importance of the synthesis of new compounds with biological activity.
Assuntos
Palavras-chave
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Infecções Estafilocócicas / Triazóis / Antibacterianos Limite: Humans Idioma: En Revista: Curr Top Med Chem Assunto da revista: QUIMICA Ano de publicação: 2020 Tipo de documento: Article País de afiliação: Brasil País de publicação: Emirados Árabes Unidos
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Infecções Estafilocócicas / Triazóis / Antibacterianos Limite: Humans Idioma: En Revista: Curr Top Med Chem Assunto da revista: QUIMICA Ano de publicação: 2020 Tipo de documento: Article País de afiliação: Brasil País de publicação: Emirados Árabes Unidos