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Genetic variants in tooth agenesis-related genes might be also involved in tooth size variations.
Cunha, Arthur S; Dos Santos, Luiza Vertuan; Marañón-Vásquez, Guido Artemio; Kirschneck, Christian; Gerber, Jennifer Tsi; Stuani, Maria Bernadete; Matsumoto, Mírian Aiko Nakane; Vieira, Alexandre Rezende; Scariot, Rafaela; Küchler, Erika Calvano.
Afiliação
  • Cunha AS; Department of Pediatric Dentistry, School of Dentistry of Ribeirão Preto, University of São Paulo, Avenida do Café s/n - Campus da USP, Sao Paulo, 4040-904, Brazil. arthur_cunha@alumni.usp.br.
  • Dos Santos LV; Department of Pediatric Dentistry, School of Dentistry of Ribeirão Preto, University of São Paulo, Avenida do Café s/n - Campus da USP, Sao Paulo, 4040-904, Brazil.
  • Marañón-Vásquez GA; Department of Pediatric Dentistry, School of Dentistry of Ribeirão Preto, University of São Paulo, Avenida do Café s/n - Campus da USP, Sao Paulo, 4040-904, Brazil.
  • Kirschneck C; Department of Orthodontics, University Medical Centre of Regensburg, Franz-Josef-Strauss-Allee 11, 93053, Regensburg, Germany.
  • Gerber JT; School of Health Science, Positivo University, Curitiba, Brazil.
  • Stuani MB; Department of Pediatric Dentistry, School of Dentistry of Ribeirão Preto, University of São Paulo, Avenida do Café s/n - Campus da USP, Sao Paulo, 4040-904, Brazil.
  • Matsumoto MAN; Department of Pediatric Dentistry, School of Dentistry of Ribeirão Preto, University of São Paulo, Avenida do Café s/n - Campus da USP, Sao Paulo, 4040-904, Brazil.
  • Vieira AR; Department of Oral Biology, School of Dental Medicine, University of Pittsburgh, 412 Salk Pavilion, 335 Sutherland Street, Pittsburgh, PA, 15261, USA.
  • Scariot R; Department of Stomatology, Federal University of Parana, Curitiba, Paraná, Brazil.
  • Küchler EC; Department of Pediatric Dentistry, School of Dentistry of Ribeirão Preto, University of São Paulo, Avenida do Café s/n - Campus da USP, Sao Paulo, 4040-904, Brazil. erikacalvano@gmail.com.
Clin Oral Investig ; 25(3): 1307-1318, 2021 Mar.
Article em En | MEDLINE | ID: mdl-32648061
OBJECTIVE: The present study aimed to evaluate if genetic variants in PAX9, MSX1, TGFα, FGF3, FGF10, FGF13, GLI2 and GLI3 are involved in TS of permanent teeth. MATERIALS AND METHODS: Pretreatment dental records from orthodontic patients were assessed prior to recruitment. Patients with tooth agenesis and congenital anomalies (including oral cleft) and/or syndromes were excluded. Dental casts were used to measure the maximum crown dimensions of all fully erupted permanent teeth except second and third molars in mesiodistal direction. Teeth with caries, occlusal wear, mesiodistal restorations, and obvious deformities were not evaluated. Genomic DNA samples were used for genotyping. The allelic discrimination of 13 genetic variants was performed. The associations between TS and genotype were analyzed by linear regression, adjusted by gender at a significance level of p ≤ 0.05. RESULTS: Genetic polymorphisms in the tooth agenesis-related genes studied here were associated with increased and decreased TS, in both maxilla and mandible (p < 0.05). CONCLUSION: This study reported associations of novel tooth agenesis-related gene variants with permanent tooth size variations. CLINICAL RELEVANCE: The presence of some genetic variants could allow the prediction of permanent tooth size.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Dente / Anodontia Tipo de estudo: Prognostic_studies Limite: Humans Idioma: En Revista: Clin Oral Investig Assunto da revista: ODONTOLOGIA Ano de publicação: 2021 Tipo de documento: Article País de afiliação: Brasil País de publicação: Alemanha
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Dente / Anodontia Tipo de estudo: Prognostic_studies Limite: Humans Idioma: En Revista: Clin Oral Investig Assunto da revista: ODONTOLOGIA Ano de publicação: 2021 Tipo de documento: Article País de afiliação: Brasil País de publicação: Alemanha