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Presence of anti-Leishmania antibodies in candidates for kidney transplantation.
de Oliveira França, Adriana; da Cunha, Giovana Masselli Rodrigues; Oliveira, Letícia Pereira; de Carvalho, Lídia Raquel; Mendes, Rinaldo Poncio; Dorval, Maria Elizabeth Cavalheiros.
Afiliação
  • de Oliveira França A; Laboratory of Clinical Parasitology, Graduate Program in Infectious and Parasitic Diseases, Universidade Federal de Mato Grosso do Sul, Campo Grande, MS, Brazil. Electronic address: dricaseal@hotmail.com.
  • da Cunha GMR; Undergraduate Program in Medicine, Universidade Federal de Mato Grosso do Sul, Campo Grande, MS, Brazil.
  • Oliveira LP; Undergraduate Program in Medicine, Universidade Federal de Mato Grosso do Sul, Campo Grande, MS, Brazil.
  • de Carvalho LR; Botucatu School of Medicine, Universidade Estadual Paulista Júlio de Mesquita Filho, Botucatu, SP, Brazil.
  • Mendes RP; Laboratory of Clinical Parasitology, Graduate Program in Infectious and Parasitic Diseases, Universidade Federal de Mato Grosso do Sul, Campo Grande, MS, Brazil; Botucatu School of Medicine, Universidade Estadual Paulista Júlio de Mesquita Filho, Botucatu, SP, Brazil.
  • Dorval MEC; Laboratory of Clinical Parasitology, Graduate Program in Infectious and Parasitic Diseases, Universidade Federal de Mato Grosso do Sul, Campo Grande, MS, Brazil.
Int J Infect Dis ; 98: 470-477, 2020 Sep.
Article em En | MEDLINE | ID: mdl-32645376
OBJECTIVES: Visceral leishmaniasis (VL) is a progressive disease that, left untreated, is typically fatal. The purpose of this investigation was to detect Leishmania sp. infection in hemodialysis patients who had received multiple blood transfusions at a private clinic in Campo Grande, Mato Grosso do Sul state, Midwest Brazil. METHODS: Fifty randomly selected volunteers were interviewed for collection of demographic, socioeconomic, and epidemiological data. Indirect immunofluorescence (titers positive when ≥1:40) and rK39 immunochromatographic tests were employed for serological investigation. RESULTS: Males predominated (60%). Age ranged from 20 to 77 years. Most subjects reported being on hemodialysis for at least one year (94%) and 84% were candidates for kidney transplantation, 67% of whom were on the waiting list. Leishmania sp. infection was detected in 32%. Contact with infected dogs was the only variable associated with infection. CONCLUSIONS: Under immunocompromised conditions, VL is opportunistic and potentially fatal. Despite existing risks, screening for VL is not performed in asymptomatic donors and recipients. The detection of anti-Leishmania antibodies in these patients reinforces the need for infection screening before immunosuppressive treatment is initiated to reduce not only the risks of VL development and severity, but also mortality rates in cases of reactivation of latent infection.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Anticorpos Antiprotozoários / Leishmania / Leishmaniose Visceral Tipo de estudo: Diagnostic_studies Limite: Adult / Aged / Animals / Female / Humans / Male / Middle aged País/Região como assunto: America do sul / Brasil Idioma: En Revista: Int J Infect Dis Assunto da revista: DOENCAS TRANSMISSIVEIS Ano de publicação: 2020 Tipo de documento: Article País de publicação: Canadá
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Anticorpos Antiprotozoários / Leishmania / Leishmaniose Visceral Tipo de estudo: Diagnostic_studies Limite: Adult / Aged / Animals / Female / Humans / Male / Middle aged País/Região como assunto: America do sul / Brasil Idioma: En Revista: Int J Infect Dis Assunto da revista: DOENCAS TRANSMISSIVEIS Ano de publicação: 2020 Tipo de documento: Article País de publicação: Canadá