Evaluation of wound healing effect of alginate film containing Aloe vera gel and cross-linked with zinc chloride.
Acta Cir Bras
; 35(5): e202000507, 2020 Jul 03.
Article
em En
| MEDLINE
| ID: mdl-32638846
PURPOSE: To develop a new wound dressing composed of alginate and Aloe vera gel and cross-linked with zinc ions. METHODS: The aloe-alginate film was characterized using scanning electron microscopy (SEM), swelling profile, mechanical properties, polysaccharide content and X-ray diffraction (XRD). Thirty Wistar rats were divided in two groups a) treated with aloe-alginate film and b) control (treated with sterile gauze). Wound contraction measurements and hystological analysis were performed on 7th, 14th and 21st days after wound surgery. RESULTS: The aloe-alginate film presented adequated mechanical resistance and malleability for application as wound dressing. There was no statistical difference in wound contraction between two groups. Histological assay demonstrated that aloe-alginate film presented anti-inflammatory activity, stimulated angiogenesis on proliferative phase and a more significant increased in collagen type I fibers and decreased type III fibers which promoted a mature scar formation when compared to control. CONCLUSIONS: The aloe-alginate film showed adequate physicochemical characteristics for wound dressing applications. The in vivo assay demonstrated that aloe-alginate film enhanced the healing process of incisional skin wounds.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Cicatrização
/
Cloretos
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Compostos de Zinco
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Preparações de Plantas
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Alginatos
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Aloe
Limite:
Animals
Idioma:
En
Revista:
Acta Cir Bras
Ano de publicação:
2020
Tipo de documento:
Article
País de publicação:
Brasil