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Evaluation of wound healing effect of alginate film containing Aloe vera gel and cross-linked with zinc chloride.
Koga, Adriana Yuriko; Felix, Julio César; Silvestre, Rodrigo Gomes Marques; Lipinski, Leandro Cavalcante; Carletto, Bruna; Kawahara, Fernanda Alexia; Pereira, Airton Vicente.
Afiliação
  • Koga AY; Fellow PhD degree, Postgraduate Program in Pharmaceutical Sciences, Universidade Estadual de Ponta Grossa (UEPG), Brazil. Technical procedures, analysis and interpretation of data, manuscript writing.
  • Felix JC; Professor, Director in Technology Institute of Paraná, Curitiba-PR, Brazil. Scientific, conception and design of the study.
  • Silvestre RGM; Master, Industrial Director in Technology Institute of Paraná, Curitiba-PR, Brazil. Scientific, conception and design of the study.
  • Lipinski LC; PhD, Associate Professor, Department of Medicine, UEPG, Ponta Grossa-PR, Brazil. Design of the study, technical procedures, statistical analysis, interpretation of data, critical revision, final approval.
  • Carletto B; Fellow PhD degree, Postgraduate Program in Pharmaceutical Sciences, UEPG, Ponta Grossa-PR, Brazil. Technical procedures, manuscript writing.
  • Kawahara FA; Master, Postgraduate Program in Biomedical Science, UEPG, Ponta Grossa- PR, Brazil. Design of the study, technical procedures.
  • Pereira AV; PhD, Associate Professor, Department of Pharmaceutical Science, UEPG, Ponta Grossa-PR, Brazil. Design of the study, technical procedures, interpretation of data, manuscript writing, critical revision, final approval.
Acta Cir Bras ; 35(5): e202000507, 2020 Jul 03.
Article em En | MEDLINE | ID: mdl-32638846
PURPOSE: To develop a new wound dressing composed of alginate and Aloe vera gel and cross-linked with zinc ions. METHODS: The aloe-alginate film was characterized using scanning electron microscopy (SEM), swelling profile, mechanical properties, polysaccharide content and X-ray diffraction (XRD). Thirty Wistar rats were divided in two groups a) treated with aloe-alginate film and b) control (treated with sterile gauze). Wound contraction measurements and hystological analysis were performed on 7th, 14th and 21st days after wound surgery. RESULTS: The aloe-alginate film presented adequated mechanical resistance and malleability for application as wound dressing. There was no statistical difference in wound contraction between two groups. Histological assay demonstrated that aloe-alginate film presented anti-inflammatory activity, stimulated angiogenesis on proliferative phase and a more significant increased in collagen type I fibers and decreased type III fibers which promoted a mature scar formation when compared to control. CONCLUSIONS: The aloe-alginate film showed adequate physicochemical characteristics for wound dressing applications. The in vivo assay demonstrated that aloe-alginate film enhanced the healing process of incisional skin wounds.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Cicatrização / Cloretos / Compostos de Zinco / Preparações de Plantas / Alginatos / Aloe Limite: Animals Idioma: En Revista: Acta Cir Bras Ano de publicação: 2020 Tipo de documento: Article País de publicação: Brasil
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Cicatrização / Cloretos / Compostos de Zinco / Preparações de Plantas / Alginatos / Aloe Limite: Animals Idioma: En Revista: Acta Cir Bras Ano de publicação: 2020 Tipo de documento: Article País de publicação: Brasil