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The effect of rosmarinic acid on deformities occurring in brain tissue by craniectomy method. Histopathological evaluation of IBA-1 and GFAP expressions.
Özevren, Hüseyin; Deveci, Engin; Tuncer, Mehmet Cudi.
Afiliação
  • Özevren H; Associate Professor, Department of Neurosurgery , Faculty of Medicine , Dicle University , Diyarbakir , Turkey . Technical procedures, manuscript preparation and writing, final approval.
  • Deveci E; PhD, Professor, Department of Histology and Embryology , Faculty of Medicine , Dicle University , Diyarbakir , Turkey . Technical procedures, histopathological examinations, manuscript preparation and writing, final approval.
  • Tuncer MC; PhD, Professor, Department of Anatomy , Faculty of Medicine , Dicle University , Diyarbakir , Turkey . Technical procedures, histopathological examinations, manuscript preparation and writing, final approval.
Acta Cir Bras ; 35(4): e202000406, 2020.
Article em En | MEDLINE | ID: mdl-32578724
PURPOSE: To investigate the role of Rosmarinic acid (RA) in the prevention of traumatic brain injury and the immunohistochemical analysis of IBA-1 and GFAP expressions. METHODS: Healthy male rats were randomly divided into 3 groups consisting of 10 rats. Groups were as follows; control group, traumatic brain injury (TBI) group, and TBI+RA group. After traumatic brain injury, blood samples were taken from the animals and analyzed with various biochemical markers. And then IBA-1 and GFAP expressions were evaluated immunohistochemically. RESULTS: Significant results were obtained in all biochemical parameters between groups. Immunohistochemical sections showed IBA-1 not only in microglia and macrophage activity but also in degenerative neurons in blood vessel endothelial cells. However, GFAP reaction and post-traumatic rosmarinic acid administration showed positive expression in astrocytes with regular structure around the blood vessel. CONCLUSION: Rosmarinic acid in blood vessel endothelial cells showed that preserving the integrity of astrocytic structure in the blood brain barrier may be an important antioxidant.
Assuntos

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Proteínas de Ligação ao Cálcio / Cinamatos / Fármacos Neuroprotetores / Craniotomia / Depsídeos / Lesões Encefálicas Traumáticas / Proteína Glial Fibrilar Ácida / Proteínas dos Microfilamentos Tipo de estudo: Evaluation_studies Limite: Animals Idioma: En Revista: Acta Cir Bras Ano de publicação: 2020 Tipo de documento: Article País de publicação: Brasil

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Proteínas de Ligação ao Cálcio / Cinamatos / Fármacos Neuroprotetores / Craniotomia / Depsídeos / Lesões Encefálicas Traumáticas / Proteína Glial Fibrilar Ácida / Proteínas dos Microfilamentos Tipo de estudo: Evaluation_studies Limite: Animals Idioma: En Revista: Acta Cir Bras Ano de publicação: 2020 Tipo de documento: Article País de publicação: Brasil