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PVA/anionic collagen membranes as drug carriers of ciprofloxacin hydrochloride with sustained antibacterial activity and potential use in the treatment of ulcerative keratitis.
Daza, Jorge Humberto Unas; Righetto, Gabriela Marinho; Chaud, Marco Vinicius; da Conceição Amaro Martins, Virginia; Lopes Baratella da Cunha Camargo, Ilana; Maria de Guzzi Plepis, Ana.
Afiliação
  • Daza JHU; Laboratory of Biochemistry and Biomaterials, São Carlos Institute of Chemistry, University of São Paulo, São Carlos, Brazil.
  • Righetto GM; Laboratory of Epidemiology and Molecular Microbiology (LEMiMo), São Carlos Institute of Physics, University of São Paulo, São Carlos, Brazil.
  • Chaud MV; Laboratory of Biomaterial and Nanotechnology, University of Sorocaba, Sorocaba, Brazil.
  • da Conceição Amaro Martins V; Laboratory of Biochemistry and Biomaterials, São Carlos Institute of Chemistry, University of São Paulo, São Carlos, Brazil.
  • Lopes Baratella da Cunha Camargo I; Laboratory of Epidemiology and Molecular Microbiology (LEMiMo), São Carlos Institute of Physics, University of São Paulo, São Carlos, Brazil.
  • Maria de Guzzi Plepis A; Laboratory of Biochemistry and Biomaterials, São Carlos Institute of Chemistry, University of São Paulo, São Carlos, Brazil.
J Biomater Appl ; 35(3): 301-312, 2020 09.
Article em En | MEDLINE | ID: mdl-32571170
Devices such as contact lenses and collagen shields have been used to improve the antibiotic bioavailability of eye drops formulations in the treatment of ulcerative keratitis. Nevertheless, these devices are not sustained drug delivery systems, and a combination with eye drops is necessary. In animal patients, it requires constant supervision by trained personnel to avoid device loss, which increases the cost of treatment. In this study, PVA/anionic collagen membranes containing ciprofloxacin or tobramycin were prepared using two different methodologies, and the release, physical and antimicrobial properties were evaluated. The membrane containing ciprofloxacin was selected as a sustained drug delivery system with antibacterial activity against Staphylococcus aureus and Escherichia coli during 48 h. Despite to be opaque, due to its heterogeneous morphology, this membrane had the adequate mechanical strength, water content, hydrophilicity, water vapor permeability, and surface pH to interact with cornea without causing discomfort. In the surface of this membrane it was observed dispersed collagen fibrils which could serve as a substrate for corneal proteinases, contributing to the reduction in stromal damage and enhancing the epithelium regeneration. These results encourage the idea these membranes are new cost-effective and safe alternatives to treat corneal ulcers in animal patients.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Soluções Oftálmicas / Álcool de Polivinil / Portadores de Fármacos / Ciprofloxacina / Úlcera da Córnea / Colágeno / Antibacterianos Limite: Humans Idioma: En Revista: J Biomater Appl Assunto da revista: ENGENHARIA BIOMEDICA Ano de publicação: 2020 Tipo de documento: Article País de afiliação: Brasil País de publicação: Reino Unido
Texto completo
Adicionar na Minha BVS
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XML
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Soluções Oftálmicas / Álcool de Polivinil / Portadores de Fármacos / Ciprofloxacina / Úlcera da Córnea / Colágeno / Antibacterianos Limite: Humans Idioma: En Revista: J Biomater Appl Assunto da revista: ENGENHARIA BIOMEDICA Ano de publicação: 2020 Tipo de documento: Article País de afiliação: Brasil País de publicação: Reino Unido