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Advancing human health in the decade ahead: pregnancy as a key window for discovery: A Burroughs Wellcome Fund Pregnancy Think Tank.
Sadovsky, Yoel; Mesiano, Sam; Burton, Graham J; Lampl, Michelle; Murray, Jeffrey C; Freathy, Rachel M; Mahadevan-Jansen, Anita; Moffett, Ashley; Price, Nathan D; Wise, Paul H; Wildman, Derek E; Snyderman, Ralph; Paneth, Nigel; Capra, John Anthony; Nobrega, Marcelo A; Barak, Yaacov; Muglia, Louis J.
Afiliação
  • Sadovsky Y; Department of Obstetrics, Gynecology, and Reproductive Sciences, Magee-Womens Research Institute, University of Pittsburgh, Pittsburgh, PA.
  • Mesiano S; Department of Reproductive Biology, Case Western Reserve University, and Department of Obstetrics and Gynecology, University Hospitals of Cleveland, Cleveland, OH.
  • Burton GJ; Centre for Trophoblast Research; University of Cambridge, Cambridge, United Kingdom.
  • Lampl M; Center for the Study of Human Health, Emory University, Atlanta, GA.
  • Murray JC; Department of Pediatrics, University of Iowa, Iowa City, IA.
  • Freathy RM; University of Exeter, Exeter, United Kingdom.
  • Mahadevan-Jansen A; Vanderbilt Biophotonics Center and Department of Biomedical Engineering, Vanderbilt University, Nashville, TN.
  • Moffett A; Department of Pathology; Centre for Trophoblast Research.
  • Price ND; Institute for Systems Biology, Seattle, WA.
  • Wise PH; Department of Pediatrics, Stanford University School of Medicine, Stanford University, Stanford, CA.
  • Wildman DE; Genomics Program, College of Public Health, University of South Florida, Tampa, FL.
  • Snyderman R; Duke Center for Personalized Health Care, Duke University Medical Center, Durham, NC.
  • Paneth N; Departments of Epidemiology and Biostatistics and of Pediatrics and Human Development, College of Human Medicine, Michigan State University, East Lansing, MI.
  • Capra JA; Department of Biological Sciences, Vanderbilt University, Nashville, TN.
  • Nobrega MA; Department of Human Genetics, University of Chicago, Chicago, IL.
  • Barak Y; Department of Obstetrics, Gynecology, and Reproductive Sciences, Magee-Womens Research Institute, University of Pittsburgh, Pittsburgh, PA.
  • Muglia LJ; Office of the President, Burroughs Wellcome Fund, Research Triangle Park, NC. Electronic address: lmuglia@bwfund.org.
Am J Obstet Gynecol ; 223(3): 312-321, 2020 09.
Article em En | MEDLINE | ID: mdl-32565236
Recent revolutionary advances at the intersection of medicine, omics, data sciences, computing, epidemiology, and related technologies inspire us to ponder their impact on health. Their potential impact is particularly germane to the biology of pregnancy and perinatal medicine, where limited improvement in health outcomes for women and children has remained a global challenge. We assembled a group of experts to establish a Pregnancy Think Tank to discuss a broad spectrum of major gestational disorders and adverse pregnancy outcomes that affect maternal-infant lifelong health and should serve as targets for leveraging the many recent advances. This report reflects avenues for future effects that hold great potential in 3 major areas: developmental genomics, including the application of methodologies designed to bridge genotypes, physiology, and diseases, addressing vexing questions in early human development; gestational physiology, from immune tolerance to growth and the timing of parturition; and personalized and population medicine, focusing on amalgamating health record data and deep phenotypes to create broad knowledge that can be integrated into healthcare systems and drive discovery to address pregnancy-related disease and promote general health. We propose a series of questions reflecting development, systems biology, diseases, clinical approaches and tools, and population health, and a call for scientific action. Clearly, transdisciplinary science must advance and accelerate to address adverse pregnancy outcomes. Disciplines not traditionally involved in the reproductive sciences, such as computer science, engineering, mathematics, and pharmacology, should be engaged at the study design phase to optimize the information gathered and to identify and further evaluate potentially actionable therapeutic targets. Information sources should include noninvasive personalized sensors and monitors, alongside instructive "liquid biopsies" for noninvasive pregnancy assessment. Future research should also address the diversity of human cohorts in terms of geography, racial and ethnic distributions, and social and health disparities. Modern technologies, for both data-gathering and data-analyzing, make this possible at a scale that was previously unachievable. Finally, the psychosocial and economic environment in which pregnancy takes place must be considered to promote the health and wellness of communities worldwide.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Resultado da Gravidez / Promoção da Saúde Tipo de estudo: Health_economic_evaluation / Prognostic_studies Aspecto: Equity_inequality Limite: Female / Humans / Pregnancy Idioma: En Revista: Am J Obstet Gynecol Ano de publicação: 2020 Tipo de documento: Article País de publicação: Estados Unidos

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Resultado da Gravidez / Promoção da Saúde Tipo de estudo: Health_economic_evaluation / Prognostic_studies Aspecto: Equity_inequality Limite: Female / Humans / Pregnancy Idioma: En Revista: Am J Obstet Gynecol Ano de publicação: 2020 Tipo de documento: Article País de publicação: Estados Unidos