Composite materials based on chitosan/gold nanoparticles: From synthesis to biomedical applications.
Int J Biol Macromol
; 161: 977-998, 2020 Oct 15.
Article
em En
| MEDLINE
| ID: mdl-32553969
Conventional strategies (Turkevich's, and modified Turkevich's methods) often synthesize gold nanoparticles (AuNPs). These pathways produce AuNPs using toxic chemistries to reduce Au(III) and stabilize Au(0) atoms upon the AuNP surfaces. To overcome the disadvantages of conventional approaches, chitosan and chitosan-based materials associate with Au(III) to produce composites. Chitosan and derivatives reduce Au(III) and stabilize AuNPs, promoting biocompatibility to the composites, following approaches in-situ. In this review, we report methods to develop chitosan/AuNPs-based composites. The main criticism is about the mechanism of composite formation. Also, we highlight applications of chitosan/AuNPs-based devices in the biomedical arena. We report the synthesis of biosensors, drug delivery devices, scaffolds, antimicrobial coatings, and others. The major criticism is concerning the material design and the lack of data regarding the composite biocompatibility. We support a critical viewpoint.
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Materiais Biocompatíveis
/
Quitosana
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Nanopartículas Metálicas
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Ouro
Limite:
Animals
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Humans
Idioma:
En
Revista:
Int J Biol Macromol
Ano de publicação:
2020
Tipo de documento:
Article
País de afiliação:
Brasil
País de publicação:
Holanda