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Composite materials based on chitosan/gold nanoparticles: From synthesis to biomedical applications.
da Silva, Ana B; Rufato, Késsily B; de Oliveira, Ariel C; Souza, Paulo R; da Silva, Elisângela P; Muniz, Edvani C; Vilsinski, Bruno H; Martins, Alessandro F.
Afiliação
  • da Silva AB; Laboratory of Materials, Macromolecules, and Composites (LaMMAC), Federal University of Technology, Apucarana 86812-460, Brazil; Group of Polymers and Composite Materials (GMPC), Chemical Department, State University of Maringá (UEM), Maringá 87020-900, Brazil.
  • Rufato KB; Laboratory of Materials, Macromolecules, and Composites (LaMMAC), Federal University of Technology, Apucarana 86812-460, Brazil; Group of Polymers and Composite Materials (GMPC), Chemical Department, State University of Maringá (UEM), Maringá 87020-900, Brazil.
  • de Oliveira AC; Laboratory of Materials, Macromolecules, and Composites (LaMMAC), Federal University of Technology, Apucarana 86812-460, Brazil; Group of Polymers and Composite Materials (GMPC), Chemical Department, State University of Maringá (UEM), Maringá 87020-900, Brazil.
  • Souza PR; Group of Polymers and Composite Materials (GMPC), Chemical Department, State University of Maringá (UEM), Maringá 87020-900, Brazil.
  • da Silva EP; Group of Polymers and Composite Materials (GMPC), Chemical Department, State University of Maringá (UEM), Maringá 87020-900, Brazil.
  • Muniz EC; Group of Polymers and Composite Materials (GMPC), Chemical Department, State University of Maringá (UEM), Maringá 87020-900, Brazil; Department of Chemistry, Federal University of Piauí (UFPI), 64049-550 Teresina, Brazil.
  • Vilsinski BH; Group of Polymers and Composite Materials (GMPC), Chemical Department, State University of Maringá (UEM), Maringá 87020-900, Brazil.
  • Martins AF; Laboratory of Materials, Macromolecules, and Composites (LaMMAC), Federal University of Technology, Apucarana 86812-460, Brazil; Group of Polymers and Composite Materials (GMPC), Chemical Department, State University of Maringá (UEM), Maringá 87020-900, Brazil; Department of Chemical and Biological
Int J Biol Macromol ; 161: 977-998, 2020 Oct 15.
Article em En | MEDLINE | ID: mdl-32553969
Conventional strategies (Turkevich's, and modified Turkevich's methods) often synthesize gold nanoparticles (AuNPs). These pathways produce AuNPs using toxic chemistries to reduce Au(III) and stabilize Au(0) atoms upon the AuNP surfaces. To overcome the disadvantages of conventional approaches, chitosan and chitosan-based materials associate with Au(III) to produce composites. Chitosan and derivatives reduce Au(III) and stabilize AuNPs, promoting biocompatibility to the composites, following approaches in-situ. In this review, we report methods to develop chitosan/AuNPs-based composites. The main criticism is about the mechanism of composite formation. Also, we highlight applications of chitosan/AuNPs-based devices in the biomedical arena. We report the synthesis of biosensors, drug delivery devices, scaffolds, antimicrobial coatings, and others. The major criticism is concerning the material design and the lack of data regarding the composite biocompatibility. We support a critical viewpoint.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Materiais Biocompatíveis / Quitosana / Nanopartículas Metálicas / Ouro Limite: Animals / Humans Idioma: En Revista: Int J Biol Macromol Ano de publicação: 2020 Tipo de documento: Article País de afiliação: Brasil País de publicação: Holanda
Texto completo
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Materiais Biocompatíveis / Quitosana / Nanopartículas Metálicas / Ouro Limite: Animals / Humans Idioma: En Revista: Int J Biol Macromol Ano de publicação: 2020 Tipo de documento: Article País de afiliação: Brasil País de publicação: Holanda