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Early Weight Gain Forecasts Accelerated Eruption of Deciduous Teeth and Later Overweight Status during the First Year.
Mennella, Julie A; Reiter, Ashley; Brewer, Benjamin; Pohlig, Ryan T; Stallings, Virginia A; Trabulsi, Jillian C.
Afiliação
  • Mennella JA; Monell Chemical Senses Center, Philadelphia, PA. Electronic address: mennella@monell.org.
  • Reiter A; Monell Chemical Senses Center, Philadelphia, PA.
  • Brewer B; University of Delaware, Newark, DE.
  • Pohlig RT; University of Delaware, Newark, DE.
  • Stallings VA; Children's Hospital of Philadelphia, Division of Gastroenterology, Hepatology and Nutrition, Philadelphia, PA.
  • Trabulsi JC; University of Delaware, Newark, DE.
J Pediatr ; 225: 174-181.e2, 2020 10.
Article em En | MEDLINE | ID: mdl-32553836
OBJECTIVES: To determine whether early diet and weight gain velocity have independent or interactive effects on deciduous teeth emergence and overweight status during the first year. STUDY DESIGN: Monthly measures of anthropometry and teeth eruption were collected during a 1-year trial (0.5-12.5 months) on formula-fed infants in which the type of randomized infant formula (cow milk or extensively hydrolyzed protein) diet significantly affected early (0.5-4.5 months) weight gain velocity. Generalized linear mixed models determined whether early diet and weight gain velocity had independent or interactive effects on timing and pattern of teeth eruption. Data from a trial on breastfed infants were used to explore effects of breast milk vs infant formula diets on teeth eruption and overweight status at 10.5 months. RESULTS: Independent of infant formula diet, velocities of weight gain had direct effects on the age of first deciduous tooth (P < .04) and number of erupted teeth over time (P < .002). Greater velocity of weight gain from 0.5 to 4.5 months caused earlier and more frequent eruption of deciduous teeth from 4.5 to 12.5 months. Exploratory follow-up analyses on the breastfed and formula-fed diet groups found early weight gain velocity (P = .001), but not diet or its interaction, had significant effects. Infants in the upper quartile for weight gain velocity had more primary teeth (P = .002), and a greater proportion of them were overweight (P < .001) at 10.5 months. CONCLUSIONS: Faster weight gain accretion forecasted accelerated primary teeth eruption and increased percentage of children who were overweight-risk factors for dental caries and obesity. TRIAL REGISTRATION: ClinicalTrials.govNCT01700205 [2012-2015] and NCT01667549 [2012-2015].
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Erupção Dentária / Aumento de Peso / Desenvolvimento Infantil / Obesidade Infantil Tipo de estudo: Clinical_trials / Prognostic_studies / Risk_factors_studies Limite: Female / Humans / Infant / Male Idioma: En Revista: J Pediatr Ano de publicação: 2020 Tipo de documento: Article País de publicação: Estados Unidos

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Erupção Dentária / Aumento de Peso / Desenvolvimento Infantil / Obesidade Infantil Tipo de estudo: Clinical_trials / Prognostic_studies / Risk_factors_studies Limite: Female / Humans / Infant / Male Idioma: En Revista: J Pediatr Ano de publicação: 2020 Tipo de documento: Article País de publicação: Estados Unidos