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White, brown, and bone marrow adipose tissue behavior in DHEA-induced PCOS mice.
Doretto-Silva, Lorena; Steiner, Marcelo Luis; Veridiano, Juliana Mora; Petri, Giuliana; Luz, Maria Cláudia de Brito; Neofiti-Papi, Bianca; Bianco, Bianca; Fonseca, Fernando Luiz Affonso; Toledo, Olga Maria Szymanski de; Fernandes, César Eduardo; Pompei, Luciano de Melo.
Afiliação
  • Doretto-Silva L; Department of Morphology and Physiology, Histology Laboratory, Centro Universitário Saúde ABC, Santo André, Brazil.
  • Steiner ML; Department of Gynecology and Obstetrics, Centro Universitário Saúde ABC, Santo André, Brazil.
  • Veridiano JM; Department of Morphology and Physiology, Histology Laboratory, Centro Universitário Saúde ABC, Santo André, Brazil.
  • Petri G; Vivarium of Centro Universitário Saúde ABC, Santo André, Brazil.
  • Luz MCB; Clinical Analysis Laboratory, Centro Universitário Saúde ABC, Santo André, Brazil.
  • Neofiti-Papi B; Department of Anatomy, Bone Metabolism Laboratory, Institute of Biomedical Sciences III, University of São Paulo, São Paulo, Brazil.
  • Bianco B; Laboratory of Genetics and Molecular Biology, Centro Universitário Saúde ABC, Santo André, Brazil.
  • Fonseca FLA; Clinical Analysis Laboratory, Centro Universitário Saúde ABC, Santo André, Brazil.
  • Toledo OMS; Department of Morphology and Physiology, Histology Laboratory, Centro Universitário Saúde ABC, Santo André, Brazil.
  • Fernandes CE; Department of Gynecology and Obstetrics, Centro Universitário Saúde ABC, Santo André, Brazil.
  • Pompei LM; Department of Gynecology and Obstetrics, Centro Universitário Saúde ABC, Santo André, Brazil.
Gynecol Endocrinol ; 37(1): 15-20, 2021 Jan.
Article em En | MEDLINE | ID: mdl-32538231
METHODS: Thirty-one female C57BL/6J mice were divided into four groups: two were treated with subcutaneous dehydroepiandrosterone (DHEA) implants and divided into normal and hypercaloric diet (HFD). Two were control and divided into normal and HFD. Presence of insulin resistance, growth, and adipocyte markers expression of white and brown adipose tissues and growth and inflammatory cytokines expression of bone marrow adipose tissue were evaluated. RESULTS: Hypercaloric diet groups presented higher total weight gain and huge growth in all fat sites, except bone marrow. They also demonstrated greater expression of adipocyte markers in sites of white adipose tissue. DHEA + HFD group showed more insulin intolerance than all other groups. DHEA shows to abrogate AdipoQ expression in all fatty tissues. CONCLUSIONS: DHEA alone does not influence adipose tissue growth, but contributes to increased insulin resistance and influences the expression of adipokines. Proximal MAT showed different behavior from the other fat depot.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Síndrome do Ovário Policístico / Resistência à Insulina / Tecido Adiposo Limite: Animals Idioma: En Revista: Gynecol Endocrinol Assunto da revista: ENDOCRINOLOGIA / GINECOLOGIA Ano de publicação: 2021 Tipo de documento: Article País de afiliação: Brasil País de publicação: Reino Unido
Texto completo
Adicionar na Minha BVS
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XML
PubMed Links
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Síndrome do Ovário Policístico / Resistência à Insulina / Tecido Adiposo Limite: Animals Idioma: En Revista: Gynecol Endocrinol Assunto da revista: ENDOCRINOLOGIA / GINECOLOGIA Ano de publicação: 2021 Tipo de documento: Article País de afiliação: Brasil País de publicação: Reino Unido