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Acquired hemophilia A and other autoimmune diseases after alemtuzumab therapy for multiple sclerosis: A report of two cases.
Comini-Frota, Elizabeth R; Campos, Angelo Pontes Freitas; Neto, Antonio Pereira Gomes; Christo, Paulo Pereira.
Afiliação
  • Comini-Frota ER; Universidade José do Rosário Vellano, Belo Horizonte, MG, Brazil.
  • Campos APF; Academic of Medicine at Universidade José do Rosário Vellano, Belo Horizonte, MG, Brazil.
  • Neto APG; Neurology Department, Santa Casa de Misericórdia Belo Horizonte, Brazil.
  • Christo PP; Department of Internal Medicine, Universidade Federal de Minas Gerais. Instituto de Ensino e Pesquisa, Santa Casa de Misericórdia de Belo Horizonte, MG, Brazil.. Electronic address: ppchristo@gmail.com.
Mult Scler Relat Disord ; 44: 102181, 2020 Sep.
Article em En | MEDLINE | ID: mdl-32531751
Alemtuzumab (ALZ) is an anti-CD52 monoclonal antibody used to treat recurrent remittent multiple sclerosis (RRMS). After ALZ infusion, there is a depletion of T and B cells expressing CD52, while the stem cells and innate immune cells are spared. Longitudinal studies with long periods of follow-ups have reported ALZ-associated autoimmune diseases, such as thrombocytopenic purpura and thyroiditis. We report two patients who developed autoimmune hemophilia A or acquired hemophilia (AHA) after ALZ infusion, one of whom developed severe vitiligo. To the best of our knowledge, these two cases of ALZ-associated AHA are the first two cases to be reported in Brazil, and the fourth and fifth AHA cases to be reported worldwide. AHA is a potential life-threatening disease if not diagnosed and treated in a timely manner. The development of AHA should be cited as a possible adverse event, and specific coagulation tests must be part of the official recommendations for patient follow-ups.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Doenças Autoimunes / Hemofilia A / Esclerose Múltipla Tipo de estudo: Diagnostic_studies / Guideline / Observational_studies / Risk_factors_studies Limite: Humans País/Região como assunto: America do sul / Brasil Idioma: En Revista: Mult Scler Relat Disord Ano de publicação: 2020 Tipo de documento: Article País de afiliação: Brasil País de publicação: Holanda
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Doenças Autoimunes / Hemofilia A / Esclerose Múltipla Tipo de estudo: Diagnostic_studies / Guideline / Observational_studies / Risk_factors_studies Limite: Humans País/Região como assunto: America do sul / Brasil Idioma: En Revista: Mult Scler Relat Disord Ano de publicação: 2020 Tipo de documento: Article País de afiliação: Brasil País de publicação: Holanda