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Relaxant Effect of Monoterpene (-)-Carveol on Isolated Human Umbilical Cord Arteries and the Involvement of Ion Channels.
Evaristo Rodrigues da Silva, Renata; de Alencar Silva, Andressa; Pereira-de-Morais, Luís; de Sousa Almeida, Nayane; Iriti, Marcello; Kerntopf, Marta Regina; Menezes, Irwin Rose Alencar de; Coutinho, Henrique Douglas Melo; Barbosa, Roseli.
Afiliação
  • Evaristo Rodrigues da Silva R; Department of Biological Chemistry, Regional University of Cariri, Crato 63105-000, CE, Brazil.
  • de Alencar Silva A; PhD student Graduate Program in Physiological Sciences, Higher Institute of Biomedical Sciences State University of Ceará-UECE, Fortaleza 60714-903, CE, Brazil.
  • Pereira-de-Morais L; PhD student in Biotechnology by the Northeastern Biotechnology Network - RENORBIO, State University of Ceará-UECE, Fortaleza 60714-903, CE, Brazil.
  • de Sousa Almeida N; Department of Biological Chemistry, Regional University of Cariri, Crato 63105-000, CE, Brazil.
  • Iriti M; Department of Agricultural and Environmental Sciences, Milan State University, via G. Celoria 2, 20133 Milan, Italy.
  • Kerntopf MR; Department of Biological Chemistry, Regional University of Cariri, Crato 63105-000, CE, Brazil.
  • Menezes IRA; Department of Biological Chemistry, Regional University of Cariri, Crato 63105-000, CE, Brazil.
  • Coutinho HDM; Department of Biological Chemistry, Regional University of Cariri, Crato 63105-000, CE, Brazil.
  • Barbosa R; Department of Biological Chemistry, Regional University of Cariri, Crato 63105-000, CE, Brazil.
Molecules ; 25(11)2020 Jun 09.
Article em En | MEDLINE | ID: mdl-32527034
Carveol is a monoterpene present in the structure of many plant products. It has a variety of biological activities: antioxidant, anticancer and vasorelaxation. However, studies investigating the effect of monoterpenoids on human vessels have not yet been described. Thus, the present study aimed to characterize the effect of (-)-carveol on human umbilical arteries (HUAs). HUA ring preparations were isolated and subjected to isometric tension recordings of umbilical artery smooth muscle contractions. (-)-Carveol exhibited a significant vasorelaxant effect on KCl and 5-HT-induced contractions, obtaining EC50 values of 344.25 ± 8.4 and 175.82 ± 4.05 µM, respectively. The participation of calcium channels in the relaxation produced by (-)-carveol was analyzed using vessels pre-incubated with (-)-carveol (2000 µM) in a calcium-free medium, where the induction of contractions was abolished. The vasorelaxant effect of (-)-carveol on HUAs was reduced by tetraethylammonium (TEA), which increased the (-)-carveol EC50 to 484.87 ± 6.55 µM. The present study revealed that (-)-carveol possesses a vasorelaxant activity in HUAs, which was dependent on the opening of calcium and potassium channels. These results pave the way for further studies involving the use of monoterpenoids for the vasodilatation of HUAs. These molecules have the potential to treat diseases such as pre-eclampsia, which is characterized by resistance in umbilical arteries.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Artérias Umbilicais / Vasodilatação / Vasodilatadores / Endotélio Vascular / Canais de Cálcio / Canais de Potássio / Monoterpenos Cicloexânicos Limite: Female / Humans Idioma: En Revista: Molecules Assunto da revista: BIOLOGIA Ano de publicação: 2020 Tipo de documento: Article País de afiliação: Brasil País de publicação: Suíça
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Artérias Umbilicais / Vasodilatação / Vasodilatadores / Endotélio Vascular / Canais de Cálcio / Canais de Potássio / Monoterpenos Cicloexânicos Limite: Female / Humans Idioma: En Revista: Molecules Assunto da revista: BIOLOGIA Ano de publicação: 2020 Tipo de documento: Article País de afiliação: Brasil País de publicação: Suíça