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Factors associated with non-completion of latent tuberculosis infection treatment in Rio de Janeiro, Brazil: A non-matched case control study.
de Aguiar, R M; da Silva Vieira, M A M; de Almeida, I N; de Paula Ramalho, D M; Ruffino-Netto, A; Carvalho, A C C; Kritski, A L.
Afiliação
  • de Aguiar RM; Tuberculosis Academic Program of Medical School, Federal University of Rio de Janeiro, Rio de Janeiro, Rio de Janeiro, Brazil.
  • da Silva Vieira MAM; Tuberculosis Academic Program of Medical School, Federal University of Rio de Janeiro, Rio de Janeiro, Rio de Janeiro, Brazil.
  • de Almeida IN; Laboratory of Mycobacteria Research of Medical School, Federal University of Minas Gerais, Belo Horizonte, Minas Gerais, Brazil. Electronic address: isabelanalmeida@gmail.com.
  • de Paula Ramalho DM; Tuberculosis Academic Program of Medical School, Federal University of Rio de Janeiro, Rio de Janeiro, Rio de Janeiro, Brazil.
  • Ruffino-Netto A; Department of Social Medicine, Faculty of Ribeirão Preto, University of São Paulo, Ribeirão Preto, São Paulo, Brazil.
  • Carvalho ACC; Laboratory of Innovation in Therapies, Education and Bioproducts, Oswaldo Cruz Institute, Fiocruz, Rio de Janeiro, Brazil.
  • Kritski AL; Tuberculosis Academic Program of Medical School, Federal University of Rio de Janeiro, Rio de Janeiro, Rio de Janeiro, Brazil.
Pulmonology ; 28(5): 350-357, 2022.
Article em En | MEDLINE | ID: mdl-32513638
INTRODUCTION: There are scarce data on the routine latent tuberculosis infection treatment (LTBIT) and factors associated with a non-completion in high tuberculosis burden countries. Therefore, in this study we aimed to evaluate the factors associated with non-completion of LTBIT. MATERIALS AND METHODS: This was a non-matched case control study conducted at a University Hospital in Rio de Janeiro, Brazil. A total of 114 cases and 404 controls were enrolled between January/1999 and December/2009. Cases were close contacts who did not complete the LTBIT and controls were the contacts that completed it. Multivariate analysis was used to investigate risk factors associated with non-completion of LTBIT among contacts in two different periods of recruitment. RESULTS: Factors associated with non-completion LTBIT included: drug use (OR 23.33, 95% CI 1.83-296.1), TB treatment default by the index case (OR 16.97, 95% CI 3.63-79.24) and drug intolerance. TB disease rates after two years of follow up varied from 0.4% to 1.9%. The number necessary to treat to prevent one TB case among contacts was 116. CONCLUSIONS: Non-completion treatment by the index case and illicit drug use were associated with not completing latent tuberculosis infection treatment and no tuberculosis disease was identified among those who completed latent tuberculosis infection treatment.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Tuberculose / Tuberculose Latente Tipo de estudo: Etiology_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Limite: Humans País/Região como assunto: America do sul / Brasil Idioma: En Revista: Pulmonology Ano de publicação: 2022 Tipo de documento: Article País de afiliação: Brasil País de publicação: Espanha
Texto completo
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Tuberculose / Tuberculose Latente Tipo de estudo: Etiology_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Limite: Humans País/Região como assunto: America do sul / Brasil Idioma: En Revista: Pulmonology Ano de publicação: 2022 Tipo de documento: Article País de afiliação: Brasil País de publicação: Espanha