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Determination of basal bone mineral density in the femur bones of male and female Wistar rats.
Hernandez-Becerra, Ezequiel; Londoño-Restrepo, Sandra M; Hernández-Urbiola, Margarita I; Jimenez-Mendoza, Daniel; Aguilera-Barreiro, Ma de Los Ángeles; Perez-Torrero, Esther; Rodríguez-García, Mario E.
Afiliação
  • Hernandez-Becerra E; Posgrado en Ciencia e Ingeniería de Materiales, Centro de Física Aplicada y Tecnología Avanzada, Universidad Nacional Autónoma de México, Campus Juriquilla, Mexico.
  • Londoño-Restrepo SM; Área de Ingeniería, Universidad del Valle de México, Campus Querétaro, Mexico.
  • Hernández-Urbiola MI; Departamento de Nanotecnología, Centro de Física Aplicada y Tecnología Avanzada, Universidad Nacional Autónoma de México, Campus Juriquilla, Mexico.
  • Jimenez-Mendoza D; Departamento de Investigación y Posgrado, Facultad de Ingeniería, Universidad Autónoma de Querétaro, Cerro de las Campanas S/n, Mexico.
  • Aguilera-Barreiro MLÁ; Departamento de Ingeniería Electromecánica, Tecnológico Nacional de México/ITS de Purísima del Rincón, Mexico.
  • Perez-Torrero E; Departamento de Ingeniería Física, División de Ciencias e Ingenierías, Universidad de Guanajuato Campus León, Mexico.
  • Rodríguez-García ME; Facultad de Ciencias Naturales, Universidad Autónoma de Querétaro, Campus Juriquilla, Mexico.
Lab Anim ; 55(1): 30-42, 2021 Feb.
Article em En | MEDLINE | ID: mdl-32460606
Changes in bone mineral content of calcium (Ca), phosphorous (P), magnesium and potassium for male and female Wistar rats during their development from 3 weeks old to adulthood (27 weeks old) were measured. Bone mineral content was related to areal bone mineral density (BMD) which was measured in vivo at the femoral neck using a calibrated X-ray transmission system to obtain basal curves as a function of the age of the specimen. Diagnostic curves were built to determine low BMD (osteopaenia) and osteoporosis in female rats fed a Ca-depleted diet (50%) based on the obtained data and the criteria established by the World Health Organization. Bone mineral content is directly related to sex and age, but P did not change throughout the experimental period. P content did not exhibit significant changes with growing, while Ca was greatest in male rats, producing significant differences in the Ca:P ratio. Male rats reach the Ca:P ratio peak before female rats. However, areal BMD does not follow the same trend. On the other hand, osteoporosis produced a 45% decrease in this parameter for young and mature adults. These results make Z-score values available to diagnose bone-mass losses and hence the possibility of improving the conditions of non-contact measurement of BMD in vivo. This technique can be used for future experiments with Wistar rats.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Osteoporose / Ratos / Densidade Óssea / Fêmur Tipo de estudo: Prognostic_studies Limite: Animals Idioma: En Revista: Lab Anim Ano de publicação: 2021 Tipo de documento: Article País de afiliação: México País de publicação: Reino Unido
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Osteoporose / Ratos / Densidade Óssea / Fêmur Tipo de estudo: Prognostic_studies Limite: Animals Idioma: En Revista: Lab Anim Ano de publicação: 2021 Tipo de documento: Article País de afiliação: México País de publicação: Reino Unido