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Genomic Instability in Peripheral Blood and Buccal Mucosal Cells of Marijuana Smokers: The Impact of Tobacco Smoke.
Souza, Daniel Vitor De; Claudio, Samuel Rangel; Da Silva, Camila Lima Feitosa; Marangoni, Kevin Pereira; Peres, Rogerio Correa; Ribeiro, Daniel Araki.
Afiliação
  • Souza DV; Department of Biosciences, Federal University of Sao Paulo, UNIFESP, Santos, SP, Brazil.
  • Claudio SR; Department of Biosciences, Federal University of Sao Paulo, UNIFESP, Santos, SP, Brazil.
  • Da Silva CLF; University São Judas Tadeu, Campus UNIMONTE, Santos, SP, Brazil.
  • Marangoni KP; University São Judas Tadeu, Campus UNIMONTE, Santos, SP, Brazil.
  • Peres RC; University São Judas Tadeu, Campus UNIMONTE, Santos, SP, Brazil.
  • Ribeiro DA; Department of Biosciences, Federal University of Sao Paulo, UNIFESP, Santos, SP, Brazil.
Asian Pac J Cancer Prev ; 21(5): 1235-1239, 2020 May 01.
Article em En | MEDLINE | ID: mdl-32458627
BACKGROUND: The aim of this study was to evaluate cytotoxic, mutagenic and genotoxic effects on buccal mucosa and peripheral blood cells from marijuana and tobacco smokers. METHODS: For this purpose, a total of 45 volunteers were distributed into four groups: CTRL group (control): individuals who did not smoke marijuana or tobacco (n = 11); Group M: Marijuana smokers (n = 13); Group T: Tobacco smokers (n = 13); Group M + T: Smokers of both marijuana and tobacco (n = 08). RESULTS: Smokers of both marijuana and tobacco led an increase of micronucleated cells on buccal mucosa when compared to control group. The occurrence of karyolysis showed significant changes in this group as well. The comet assay data revealed genetic damage in peripheral blood cells for all groups of smokers. CONCLUSION: In summary, our results showed that marijuana and /or tobacco are able to induce genetic damage and cytotoxicity in oral and peripheral blood cells.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Fumaça / Células Sanguíneas / Cannabis / Fumar / Instabilidade Genômica / Mucosa Bucal Tipo de estudo: Observational_studies / Prognostic_studies Limite: Adult / Female / Humans / Male Idioma: En Revista: Asian Pac J Cancer Prev Assunto da revista: NEOPLASIAS Ano de publicação: 2020 Tipo de documento: Article País de afiliação: Brasil País de publicação: Tailândia
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Fumaça / Células Sanguíneas / Cannabis / Fumar / Instabilidade Genômica / Mucosa Bucal Tipo de estudo: Observational_studies / Prognostic_studies Limite: Adult / Female / Humans / Male Idioma: En Revista: Asian Pac J Cancer Prev Assunto da revista: NEOPLASIAS Ano de publicação: 2020 Tipo de documento: Article País de afiliação: Brasil País de publicação: Tailândia