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Clinicopathologic characteristics and survival of patients with primary effusion lymphoma.
Aguilar, Cristian; Laberiano, Caddie; Beltran, Brady; Diaz, Cecilia; Taype-Rondan, Alvaro; Castillo, Jorge J.
Afiliação
  • Aguilar C; Laboratorio de Patologia, Instituto Nacional Cardiovascular, Lima, Peru.
  • Laberiano C; Traslational Molecular Pathology, University of Texas, MD Anderson Cancer Center, Houston, USA.
  • Beltran B; Instituto de Patologia y Biologia Molecular Arias Stella, Lima, Peru.
  • Diaz C; Department of Oncology and Radiotherapy, Hospital Nacional Edgardo Rebagliati Martins, Lima, Peru.
  • Taype-Rondan A; Department of Pathology, Hospital Nacional Edgardo Rebagliati Martins, Lima, Peru.
  • Castillo JJ; Universidad San Ignacio de Loyola, Unidad de Investigación para la Generación y Sintesis de Evidencias en Salud, Lima, Peru.
Leuk Lymphoma ; 61(9): 2093-2102, 2020 09.
Article em En | MEDLINE | ID: mdl-32449626
Primary effusion lymphoma (PEL) is an aggressive B-cell lymphoma confined to body cavities and universally associated with human herpesvirus type 8 infection. The prognosis of this entity remains poor, with a median survival time of 6 to 9 months. To better understand the clinicopathologic features of the disease and identify possible prognostic factors, we performed a systematic review of the literature for cases of PEL, including 2 previously unreported cases from our institution. PEL was more prevalent in men (92%), with a median age at diagnosis of 55 years. The median overall survival for the entire series was 6 months. Peritoneal involvement (HR:1.62; 95% CI:1.06-2.48) and elevated serum lactate dehydrogenase (LDH) levels (HR:2.50; 95% CI:1.21-5.19) were associated with higher risk of death, while pericardial involvement (HR:0.43; 95% CI:0.20-0.94) was associated with lower risk of death. Therefore, effusion site and serum LDH levels are potential prognostic factors in patients with PEL.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Síndrome da Imunodeficiência Adquirida / Infecções por Herpesviridae / Herpesvirus Humano 8 / Linfoma de Efusão Primária Tipo de estudo: Diagnostic_studies / Prognostic_studies / Systematic_reviews Limite: Humans / Male Idioma: En Revista: Leuk Lymphoma Assunto da revista: HEMATOLOGIA / NEOPLASIAS Ano de publicação: 2020 Tipo de documento: Article País de afiliação: Peru País de publicação: Estados Unidos
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Síndrome da Imunodeficiência Adquirida / Infecções por Herpesviridae / Herpesvirus Humano 8 / Linfoma de Efusão Primária Tipo de estudo: Diagnostic_studies / Prognostic_studies / Systematic_reviews Limite: Humans / Male Idioma: En Revista: Leuk Lymphoma Assunto da revista: HEMATOLOGIA / NEOPLASIAS Ano de publicação: 2020 Tipo de documento: Article País de afiliação: Peru País de publicação: Estados Unidos